Scientist II, Process Chemistry

at  Blueprint Medicines

Cambridge, Massachusetts, USA - 02139

Start DateExpiry DateSalaryPosted OnExperienceSkillsTelecommuteSponsor Visa
Immediate19 Feb, 2022Not Specified20 Nov, 20212 year(s) or aboveProblem Solving,Drive,Addition,Small Molecules,Organic Chemistry,Interpersonal Skills,Management Skills,Connections,It,Clinical Development,Technology Transfer,Process Optimization,Route Development,Collaboration,Cmo,PreparationNoNo
Required Visa Status:
CitizenGC
US CitizenStudent Visa
H1BCPT
OPTH4 Spouse of H1B
GC Green Card
Employment Type:
Full TimePart Time
PermanentIndependent - 1099
Contract – W2C2H Independent
C2H W2Contract – Corp 2 Corp
Contract to Hire – Corp 2 Corp

Description:

SCIENTIST II, PROCESS CHEMISTRY

Cambridge, MA
Requisition Number: 89
Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and hematologic disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, to rapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for genomically defined cancers, systemic mastocytosis, and cancer immunotherapy.

WHAT BASIC QUALIFICATIONS DO WE REQUIRE?

  • Master’s or Bachelor’s degree in organic chemistry, in addition to 5 years of applicable experience in a pharmaceutical or biotechnology industry role is required

OR

  • PhD (or Postdoc) in organic chemistry in addition to 2 years of experience in a pharmaceutical or biotechnology industry role is required
  • Experience with early phase route development and process optimization
  • Experience with technology transfer and outsourced work on process development, kilo-lab preparation, and plant production
  • Experience in API manufacturing associated with small molecules in clinical development
  • Management of drug substance development and manufacture under an outsourcing model
  • Provides scientific guidance to CMO’s on the assigned programs; helps trouble-shooting development and production issues.
  • Management of on-time API deliveries for drug safety studies, formulation development, preclinical, and clinical studies
  • Preparation of CMC documents suitable for regulatory and/or patent filings.
  • At home in a results-driven, highly accountable environment where you can make a clear impact

WHAT ADDITIONAL QUALIFICATIONS ARE WE SEEKING?

  • Resourcefulness/ Flexibility – The ability to adapt to working optimally within a variety of situations; adapts to change and to changes in job demands
  • Communication and Partnership – Ability to optimally express ideas in written and oral context; collaboration, team-building skills and interpersonal skills; genuine desire to be on a team and contribute to organizational and team goals
  • Effective Planning – Demonstrated effective time management skills and execution
  • Perseverance – Pursues tasks with energy, drive and initiative; comfortable in an accountable environment where you can make an impact
  • Problem Solving – Ability to understand a situation or problem by breaking it down into smaller pieces using a detailed approach and to identify patterns and connections between situations that are not obviously related
  • Relationship Building – Builds productive working relationships across a diverse spectrum of people

WHO WE ARE:

We don’t think in small steps. We think in giant leaps.
We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.
We know that what each and every one of us matters and that our success depends on our ability to work together in a diverse community. We believe we are at our best as a company when our employees are thriving and we foster a culture that provides opportunities to grow and develop professionally, while also having fun.

Responsibilities:

WHAT WILL YOU DO?

Blueprint Medicines is seeking an outstanding candidate for a Scientist II in Process Chemistry R&D. This candidate will be responsible for the planning and execution of all activities related to the development and manufacturing oversight of small molecule API. This includes contributing to the integration of CMC plans from pre-IND/IMPD through NDA/MAA in support of Blueprint Medicines’ pre-clinical and clinical programs.

WHAT WILL BE YOUR RESPONSIBILITIES?

Blueprint Medicines seeks an exceptional candidate for the position of Scientist/Senior Scientist of Process Chemistry Research and Development. This position reports into the Director of Process Chemistry R&D. The right candidate will possess an in-depth understanding of small molecules DS-related activities.

  • Oversee the design, planning, and execution of multi-step organic syntheses of small molecules as a member of cross-functional development teams
  • Support drug substance scale-up, GLP, and GMP manufacturing activities
  • Work with internal and external teams, as well as preferred Contract Development and Manufacturing Organizations (CDMOs) to efficiently design and deliver high quality chemical processes for API delivery
  • Work closely with Medicinal Chemists to ensure synthetic route, pharmaceutical form, and compound properties are appropriate for development
  • Represent Process Chemistry R&D on CMC Subteams
  • Proactively work to manage vendors with regard to scope, timelines, and deliverables
  • Drafting and reviewing of technical and GMP documents, scientific manuscripts, CMC-regulatory documents for regulatory filings and patent applications


REQUIREMENT SUMMARY

Min:2.0Max:5.0 year(s)

Pharmaceuticals

Pharma / Biotech / Healthcare / Medical / R&D

Clinical Pharmacy

Graduate

A pharmaceutical or biotechnology industry role is required

Proficient

1

Cambridge, MA, USA