Upstream Scientist, Pilot Plant Operations

at  AbCellera Biologics

AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.
We are seeking a highly motivated Upstream Scientist to join the Manufacturing, Science & Technology team. In this role, based in beautiful Vancouver, Canada, you will focus on implementing and operationalizing a 200L scale pilot manufacturing facility to generate materials or CMC development, including providing high quality representative material for regulatory submission enabling GLP toxicology studies. You will also play a key role in technology transfer and scale-up to enable successful antibody production from the bench to manufacturing scale.

REQUIRED QUALIFICATIONS AND EXPERIENCE

• 5+ years of industrial experience in process development, manufacturing, and/or MSAT
• Bachelor’s degree in biotechnology, chemical/biochemical engineering, or another relevant life-science discipline
• Hands-on experience in mammalian cell culture and the operation of bioreactors. Experience using single-use technologies is an advantage
• Expertise in cell culture metrics, including agitation, viable cell density, metabolite consumption rates, pH, dissolved oxygen, and media and feed composition and strategy
• Experience in scale-up, technology transfer, batch documentation, data analysis and data management
• Demonstrated experience in batch production is desirable
• Experience in manufacturing monoclonal and/or bispecific antibodies is an asset

Please refer the Job description for details