Advisor – Cell Therapy Engineering– Lilly Gene Therapy at Lilly

Boston, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

02 Jan, 26

Salary

224400.0

Posted On

04 Oct, 25

Experience

10 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Molecular Biology, Protein Engineering, CAR Constructs, Lentiviral Vector Production, High-Throughput Workflows, Functional Assays, Collaboration, Mentoring, Troubleshooting, Process Optimization, CRISPR, Automation Platforms, In Vivo Models, Data Analysis, Communication, Cytotoxicity Assays

Industry

Pharmaceutical Manufacturing

Description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Join the rapidly expanding Lilly Gene Therapy team at Eli Lilly. We invent, characterize, and advance novel gene therapy reagents for a wide range of clinical applications, working cross-functionally across disease areas and platforms. Our goal is to deliver on the promise of gene therapy for patients worldwide. Job Responsibilities: Design, build, and optimize CAR constructs using advanced molecular biology and protein engineering strategies. Oversee and perform lentiviral vector (LVV) production, packaging, and characterization to support discovery-stage programs. Develop and implement high-throughput workflows for construct generation, LVV production, and functional screening. Conduct and interpret CAR functional assays in primary immune cells, including cytotoxicity, cytokine release, and proliferation assays. Collaborate cross-functionally with Immunology, Oncology, Computational Biology, and Translational teams to advance cell therapy programs. Lead and mentor a team of associates working on molecular biology and vector biology workflows. Maintain detailed experimental records, analyze data, and present findings to internal stakeholders. Contribute to troubleshooting, process optimization, and technology development initiatives. Basic Qualifications: Ph.D. in Molecular Biology, Cell Biology, Immunology, Biotechnology, Chemical Engineering or related scientific field OR M.S with 10+ years of relevant industry experience. Additional Skills: Proven expertise in molecular biology techniques (cloning, mutagenesis, PCR/qPCR/ddPCR, sequencing). Hands-on experience with CAR construct design and functional assays in primary immune cells. Strong background in lentiviral vector production, packaging, and characterization. Demonstrated ability to lead and mentor junior scientists in a laboratory setting. Experience with site-directed integration technologies (e.g., CRISPR, recombinase systems). Familiarity with high-throughput screening approaches and automation platforms. Exposure to vivo models for CAR-T evaluation and high-throughput in vivo screening. Excellent problem-solving skills and ability to troubleshoot complex workflows. Strong communication and collaboration skills in a multidisciplinary environment. Additional Information: This role may require up to 10–15% travel for conferences or training. Location: 15 Necco Street, Boston Seaport, MA 02210. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $138,000 - $224,400 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

Responsibilities

The Advisor will design, build, and optimize CAR constructs and oversee lentiviral vector production to support discovery-stage programs. They will also collaborate with cross-functional teams and lead a team of associates in molecular biology workflows.