Associate Formulation Development Scientist at PhosphorexInc

Hopkinton, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

22 Sep, 26

Salary

0.0

Posted On

24 Jun, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Formulation Development, Characterization of Particulate Systems, Microfluidics, Lipid Nanoparticles, Polymeric Nanoparticles, Tangential Flow Filtration, Particle Size Analysis, Zeta Potential, Encapsulation Efficiency, In Vitro Release, Lyophilization, SOP Preparation

Industry

Biotechnology Research

Description

Description The Associate Scientist is a specialist in the formulation and characterization of particulate based drug delivery systems including lipid and polymeric nanoparticles. The Associate Scientist participates in the development and optimization of formulations to enable cell and tissue targeting contributing to the development of novel therapeutics. They perform hands-on experiments in a laboratory setting, leading the execution of upstream (buffer prep, emulsification, microfluidics) and downstream (buffer exchange, concentration, etc.) formulation development activities. The Associate Scientist is a team player who has laboratory and technical experience with a high attention to detail and desire to work in a fast-paced environment and contribute to a result orientated team. Role and Responsibilities Assist in development and optimization of particulate based drug delivery systems to enable delivery of nucleic acids, peptides and small molecules for cell and tissue targeting by: Preparing polymeric and lipid-based microsphere and nanoparticle formulations via microfluidics, emulsification, etc. Purification and downstream processing of formulations via dialysis, centrifugation and tangential flow filtration Characterization of formulations including particle size analysis, zeta potential, drug content, encapsulation efficiency and in vitro release Evaluating short term stability of frozen and lyophilized formulations to support proof of concept animal studies. Collaborate with project team(s) to define and execute project plans to facilitate the development and optimization of formulations and processes to support feasibility and pre-clinical studies. Work collaboratively across multiple departments (Operations, Analytical Services, Process Development) to facilitate project teams’ ability to successfully meet project objectives in a timely and organized fashion. Prepare and review documents including experimental methods, batch records, SOPs, and reports. Maintain detailed laboratory notebook. Adhere to Phosphorex’s Environmental Health and Safety practices and SOPs to maintain a safe, clean, and organized work environment free of safety hazards. Requirements Qualifications and Education Requirements Bachelor’s degree in chemistry, pharmacy, pharmaceutical sciences, engineering, or other relevant discipline with 0-2 years relevant experience Strong analytical and critical thinking abilities Excellent organizational skills, attention to detail and ability to manage multiple priorities in a fast-paced and dynamic environment. Excellent verbal and written communication skills and ability to collaborate effectively with scientists and engineers working in other disciplines. Ability to work independently as well as with an interdisciplinary team in a highly collaborative environment. Demonstrated ability to contribute to multiple projects in parallel. Well versed with Microsoft Office applications. Preferred Skills Prior experience with microfluidic fabrication of Lipid Nanoparticles (LNPs) and/or characterization of LNPs. Prior experience with biodegradable polymeric systems and development of micro-and nano-particle formulations. Experience in CDMO environment.

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Responsibilities

The Associate Scientist develops and optimizes particulate-based drug delivery systems using microfluidics and emulsification. They are responsible for the purification, characterization, and stability testing of formulations to support pre-clinical studies.