Associate Manufacturing Scientist I (2nd shift) at Arrowhead Pharmaceuticals

Verona, Wisconsin, United States -

Full Time

Start Date

Immediate

Expiry Date

19 Dec, 25

Salary

73000.0

Posted On

20 Sep, 25

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Chemistry, Biochemistry, Engineering, GMP Compliance, Documentation, Teamwork, Attention to Detail, Oligonucleotide Synthesis, Chromatography, Reagent Preparation, Column Packing, Mobile Phase Preparation, Fraction Collection, TFF Operation, Lyophilization, Safety Protocols

Industry

Biotechnology Research

Description

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Associate Manufacturing Scientist I (second shift) will assist in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations. 2nd shift work hours are 1pm – 11:30pm and includes a shift differential. Responsibilities Follow batch records, SOPs, and work instructions to detail Document all operations in batch records and notebooks Comply with GMP protocols Assist other chemists within the CMC group during synthesis and chromatography of oligonucleotides including: Reagent solution preparation Column Packing Mobile phase preparation Fraction collection Operate TFF to desalt purified RNA solutions Operate a lyophilizer and package solid drug substance Execute processes as part of a team to ensure production timelines are kept and quality product is produced Maintain a clean work space Maintain safety by wearing required personal protective equipment Requirements: Bachelor's degree in chemistry, biochemistry, engineering, or related scientific field Experience working in a GMP setting and controlled documentation Good verbal and written communication skills Ability to work in a team environment Ability to pay attention to detail Wisconsin pay range $63,000—$73,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Responsibilities

The Associate Manufacturing Scientist I will assist in the synthesis and purification of large scale oligonucleotides while complying with GLP/GMP protocols. Responsibilities include following batch records, documenting operations, and assisting chemists in various synthesis and chromatography tasks.