Biotech Upstream Process Development Senior Scientist at Demo S.A.

Athens, Attica, Greece -

Full Time

Start Date

Immediate

Expiry Date

28 Dec, 25

Salary

0.0

Posted On

29 Sep, 25

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Mammalian Cell Culture, Bioreactor Systems, Process Optimization, Experimental Plans, Process Scaleup Strategies, Risk Assessments, Technology Transfer, Process Characterization, Data Analysis, DoE Principles, Statistical Tools, Documentation, Communication Skills, Problem-Solving, Critical Thinking, Team Player

Industry

Pharmaceutical Manufacturing

Description

At DEMO SA, one of the world’s largest pharmaceutical manufacturers in injectable facilities, our new Biotechnology Center in Athens, Agios Stefanos, is now fully operational. Biotechnology is transforming healthcare, and DEMO is at the forefront with cutting-edge research and innovation. As we continue to grow, we are looking for a high-caliber Upstream Senior Scientist to join our team. Main duties and Responsibilities: Design and execute early stage as well as late-stage mammalian cell culture experiments at both lab and pilot scales. Hands on experience with High-throughput bioreactor systems like Ambr250. Perform process optimization leading to the process lock. Assist in the design and execution of experimental plans to understand the process and its robustness (Identification and characterization of Critical Process Parameters and their link with Critical Quality Attributes) Provide technical support, develop process scaleup strategies, prepare risk assessments and support technology transfer from laboratory to pilot and to commercial scale. Review process development, process transfer, scale-up batches and documentation. Perform SDM establishment and qualification & design and perform Process Characterization studies. Responsible for experimental data analysis and documentation Experienced in the DoE principles and able to analyze complex datasets using statistical tools (e.g., JMP DoE, MVDA, etc.). Document experimental protocols, results, and technical reports in compliance with R&D, QA & regulatory standards. MSc in biology, biotechnology or related field PhD degree in a field related to biotechnology, bioengineering or biochemistry will be highly appreciated. Strong background and hands-on experience at least 3 years in upstream processing of biotherapeutics (biosimilars and monoclonal antibodies preferred). Proficiency in operating and troubleshooting bioreactors (Lab & Pilot scale) Sound knowledge of regulations required for analytical development of biotech products, preferably in biosimilars development. Excellent communication skills both verbal and written. Strong problem-solving attitude, critical thinking. Resilience and ability to work under pressure. Team player. The Company offers competitive remuneration, continuous learning and development opportunities, and a friendly and challenging working environment.

Responsibilities

The Senior Scientist will design and execute mammalian cell culture experiments at lab and pilot scales, focusing on process optimization and technology transfer. They will also provide technical support and perform data analysis to ensure process robustness and compliance with regulatory standards.