Cellarity: Director, Medicinal Chemistry at Flagship Pioneering, Inc.

Somerville, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

06 Jan, 26

Salary

0.0

Posted On

08 Oct, 25

Experience

10 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Functional Genomics, Next Generation Sequencing, Data Generation, CRISPR, Project Management, Communication Skills, Collaboration, Single Cell Transcriptomics, CRO Management, Experimental Protocols, Biology, Machine Learning, Assay Development, Exploratory Biology, Data-Driven Mindset, Hematology, Immunology

Industry

Biotechnology Research

Description

What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way. What this position is all about: Cellarity is seeking an experienced and highly motivated Principal Scientist with expertise in Functional Genomics and Next Generation Sequencing (NGS) to play a vital role in the company’s efforts to enhance and expand our perturbation data engine. The candidate will be responsible for planning and executing large-scale data generation efforts, working with CROs and managing junior scientists. The successful candidate will work cross-functionally, particularly with our Machine Learning, and Biology teams to build meaningful datasets that drive our Foundation Models. The ideal candidate must be independent, goal oriented, have excellent communication skills, be willing to learn new skills and work in a fast-paced entrepreneurial environment. What you would be responsible for: Lead from the bench data generation efforts to support our expanding platform capabilities Plan and execute Next Generation Sequencing (NGS) experiments Develop and execute CRISPR based perturbation screens Manage CROs and mentor junior scientists Collaborate with scientists from Machine Learning, Assay Development, and Exploratory Biology as part of our efforts to enhance our platform tools Maintain detailed records of experimental protocols and data in electronic laboratory notebooks Represent Platform Biology as a Biology Lead in Platform expansion efforts What experiences will you need: Ph.D degree in cell biology or related field, with 8-10 years of industry experience; MS with 15+ years of experience will be considered Demonstrated ability leading projects and driving programs to key decisions points Extensive experience in Next Generation Sequencing methodologies including single cell transcriptomics Experienced managing CROs, including transfer and implementation of SOP and assays Previous experience performing CRISPR screens (pooled or arrayed) Excellent communication skills What sets you apart: Experience in hematology/immunology Led a project team with 5-10 members Innovative mindset focused on pushing scientific boundaries Data-driven, willingness to abandon dogma when science leads us to new places Strong desire to work collaboratively within and across teams What it’s like to work at Cellarity At Cellarity, we Push Boundaries: We create a legacy with breakthrough science in service of patients. Inject Energy: We build strengths from different perspectives and tell it like it is Own it: We transcend our job descriptions and relentlessly follow through on our commitments. Go all out: We work quickly and with conviction. Company Summary: Cellarity’s mission is to fundamentally redesign the way drugs are created for the sake of bringing new hope to patients. By shifting the focus from a single target to the underlying cellular dysfunction, we unravel the complexity of disease biology and create medicines that were never before possible. The company has developed unique capabilities that link biology and chemistry with high dimensional -omic data from which we design medicines against the cellular signature of disease. The Cellarity platform allows us to uncover new biology in diseases even in the absence of known causal targets. Cellarity is a privately held, clinical-phase drug discovery startup using AI and single-cell omics to develop life-changing medicines that are unreachable by traditional methods of drug discovery. Cellarity is a product of Flagship Pioneering's venture creation engine, which has conceived and created companies such as Moderna (NASDAQ: MRNA), Generate: Biomedicines, and Lila Sciences. Cellarity is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Cellarity does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Cellarity or its employees is strictly prohibited unless contacted directly by Cellarity’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Cellarity, and Cellarity will not owe any referral or other fees with respect thereto. #LI-TD1

Responsibilities

The candidate will lead data generation efforts to support the company's platform capabilities and plan and execute NGS experiments. They will also manage CROs, mentor junior scientists, and collaborate with various teams to enhance platform tools.