Co-op, Medicinal Chemistry at Blueprint Medicines

Cambridge, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

29 Dec, 25

Salary

32.0

Posted On

30 Sep, 25

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Medicinal Chemistry, Organic Synthesis, Drug Discovery, Chemical Reactions, Purification Techniques, Analytical Techniques, Structure-Based Drug Design, Data Analysis, Multidisciplinary Team Collaboration, Record-Keeping, Presentation Skills, Chemistry Education, Problem Solving, Attention to Detail, Time Management, Communication Skills

Industry

Biotechnology Research

Description

Co-op, Medicinal Chemistry Address: 45 Sidney Street Cambridge, MA, 02139 Blueprint Medicines, a Sanofi company, is a global biopharmaceutical company that invents life-changing medicines. We seek to improve and extend patients' lives by solving important medical problems, with a focus on allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a track record of success with two approved medicines, including AYVAKIT/AYVAKYT (avapritinib) which we are bringing to patients with SM in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases and solid tumors. Responsibilities: We are seeking a highly motivated and enthusiastic co-op intern to join our medicinal chemistry team. This lab-based internship will provide an introductory experience into the drug discovery process. Working under the supervision of a senior chemist, the intern will design and synthesize novel chemical matter for evaluation in a preclinical program. The intern will analyze and interpret data to build upon existing structure activity relationships, informing the design of subsequent generations of targets. In addition to developing their skills in multistep organic synthesis, the intern will learn and apply basic principles of medicinal chemistry, including structure-based drug design, ADME properties, and PK optimization. Projects will be crafted along one or multiple of the following key areas based on interest and business needs: Propose potential synthetic routes and carry out multistep organic synthesis to generate novel chemical matter. The chemist will utilize a variety of chemical reactions, purification techniques (extraction, crystallization, silica chromatography, reverse-phase HPLC, etc.), and analytical techniques (LC-MS, NMR, etc.), and practice good record-keeping in an electronic notebook. Present data and summarized results both orally and in written form, within multidisciplinary team meeting Take detailed notes about the experimental design and conditions, record these experimental results in both electronic notebook and presentation format Learn and practice the basic principles of structure-based drug design (SBDD) through data analysis and practice designing new compounds, using software such as D360, LiveDesign, Flare, Spark, and Maestro. Meet weekly with their manager to discuss progress and review relevant topics in organic and medicinal chemistry (tailored to the intern’s level of chemistry education). Attend weekly chemistry team meetings and provide a monthly update to the chemistry team. Perform other duties as assigned. ONSITE EXPECTATIONS (DAYS PER WEEK): This is a lab-based position, we expect 5 days on site. Qualifications: Senior, or Master’s/PhD level, pursuing a degree in Chemistry or a related major Must have successfully completed Organic Chemistry courses (I and II or equivalent) with lab. What additional qualifications will make you a stronger candidate? Interested in organic synthesis, medicinal chemistry, chemical biology, and drug discovery. Experience in multi-step organic syntheses preferred. Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism Our Co-op Program: Blueprint’s Co-op program is ~6 months long. The program is designed to provide students with deep functional expertise within their department and a broad understanding of the life sciences industry. Co-ops are paired with dedicated mentors for personalized learning and career development guidance. The program includes lunch and learn sessions, networking events, a student volunteer day, and other networking opportunities. It culminates in a final poster presentation where interns showcase their work. Dress Code: Blueprint’s offices are a business casual environment. Business casual means attire that is professional but also relaxed, such as slacks or business dress pants, skirts/dresses, khakis, chinos, or dark jeans without holes paired with button-down shirts, sweaters, blouses, or polo shirts and closed-toed shoes. It typically excludes formal suits or very casual clothing such as athletic wear or flip flops. Spring 2026 Co-op Program Dates: Monday, January 5th – Friday, June 26th Pay Range: Our Co-ops are paid hourly based on previous Co-op experience. The expected pay range for this role is $27.00 - $32.00 per hour. Who will my employer be? You will be employed by Magnit, LLC for all purposes and not Blueprint Medicines, a Sanofi Company. As your employer, Magnit will assign you to provide services to Blueprint as a co-op or intern. Under this arrangement, co-ops and interns will have the opportunity to learn about Blueprint Medicines, a Sanofi Company and gain meaningful hands-on experience. Please note: Co-op and interns are not employees of Blueprint in any way, and do not qualify for participation in Blueprint’s benefit plans. Equity, Diversity, Inclusion and Affirmative Action “To do our best work we need different viewpoints. Therefore, we celebrate diversity and embrace inclusion. As an equal opportunity employer, we are dedicated to building a team that represents a variety of backgrounds, perspectives, and skills. We strive to ensure that we maintain a positive and enriching work environment for all.” For more information on Magnit’s privacy notice, click on privacy notice. Magnit, LLC recognizes the importance of individually held beliefs re: appropriate dress/attire and will reasonably accommodate an employee’s religious beliefs unless the accommodation creates an undue hardship. Those requesting attire accommodation based on religious beliefs should reach out to their Magnit representative. Magnit is a Global industry leader with one simple goal of shaping and delivering the next chapter in workforce management for our employees, clients, suppliers, and partners around the world. Why Blueprint? At Blueprint Medicines, a Sanofi Company, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

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Responsibilities

The intern will design and synthesize novel chemical matter for evaluation in a preclinical program while analyzing and interpreting data to inform the design of subsequent generations of targets. They will also learn and apply basic principles of medicinal chemistry and present their findings within a multidisciplinary team setting.