Director, Translational Science Lead Respiratory at GSK

Stevenage, England, United Kingdom -

Full Time

Start Date

Immediate

Expiry Date

23 May, 26

Salary

0.0

Posted On

22 Feb, 26

Experience

10 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Translational Science, Biomarker Strategy Development, Clinical Development, Translational Leadership, Translational Innovation, Cross-functional Collaboration, External Partnerships, Matrix Leadership, Mentorship, Budget Management, Portfolio Governance, Data Interpretation, Patient Stratification, Assay Validation, Business Development Diligence

Industry

Pharmaceutical Manufacturing

Description

İş Yeri: UK - Hertfordshire - Stevenage, GSK HQ, USA - Massachusetts - Waltham, USA - Pennsylvania - Upper Providence Yayın tarihi: Feb 19 2026 Business Introduction At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Position Summary The Respiratory, Immunology and Inflammation Translational Unit (RIITU), within RIIRU therapy area is accountable for end-to-end disease area translational science to inform therapy area and program level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations. We are looking for a dynamic individual to excel in the following responsibilities. Key Responsibilities: Disease Biomarker Strategy Development and Delivery: o Partner with the Clinical Teams, Research Technologies and the Development organization with focus on Respiratory portfolio to identify, establish biomarkers for decision making throughout clinical development phases and aligned with the overall research and development goals. This will include the identification, prioritization and validation of disease relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and differentiated response prediction, their deployment into clinical studies and interpretation of data/results. Translational Leadership: o Provide strategic leadership contributing to deep understanding of Disease areas enabling the development and execution of translational research disease strategies to support the discovery and development of novel differentiated therapeutics including evaluation and diligence of business development opportunities. Translational innovation: o Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives, biomarker development and validation working in collaboration with platform teams and within a multi-functional matrix environment. o Identify and guide validation of human assays (cells, tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas, disease tissue multi-omics data and genetic resources (external or proprietary). Cross-functional Collaboration: o Collaborate closely with cross-functional teams including the Translational, Disease Teams, Human Genetics & Genomics, biology groups, biomarker platforms, Medicine Development Teams, HBSM, data-sciences, regulatory affairs, business development and commercial to ensure seamless integration of translational research and biomarker strategies across the drug development lifecycle. External Partnerships: o Establish and maintain strategic collaborations with academic institutions, contract research organizations (CROs), and other external partners to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities. o Foster a network of external experts and key opinion leaders to stay at the forefront of translational science and biomarker advancements across the industry. o Contribute to evaluation and diligence of business development opportunities. Matrix Leadership: o Provide mentorship, guidance, and professional development opportunities to ensure a high-performing and motivated team. o Manage disease and project level resources, budgets, and timelines to ensure the successful execution of projects and achievement of milestones and RITU objectives. o Represent RITU at portfolio governance reviews providing critical input to pipeline and investment decision making. Why You? Basic Qualification We are seeking professionals with the following required skills and qualifications to help us achieve our goals Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field) Extensive experience in translational science and biomarker development ideally within the pharmaceutical or biotechnology industry. Recognised translational/biomarker expert in scientific community through publications and contributions to the field. Experience of translation and biomarkers implementation in Respiratory indications Experience of working in a clinical trial setting, working as part of a clinical study and experience of authoring and oversight of clinical and regulatory documents Preferred Qualification If you have the following characteristics, it would be a plus Knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation. Broad knowledge in technologies and methods used in translational research. Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones. Experience leading/managing external collaborations and evaluation of business development opportunities. Strong management skills, with the ability to prioritize and manage multiple objectives to meet timelines while maintaining attention to detail and high-performance standards. Excellent inclusive matrix leadership skills, with the ability to create psychological safety, inspire and motivate a team towards achieving common goals. Working Model This role is based in the United Kingdom or the United States and follows a hybrid working model. You will be expected to work on site regularly to collaborate with your team and partners. How to apply If this role inspires you, please apply with your CV and a short cover note describing a recent translational achievement. Tell us what you did, why it mattered, and the impact it had. We welcome people from all backgrounds and value inclusion in how we hire and lead. We look forward to hearing from you. • If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

Responsibilities

The role is accountable for end-to-end disease area translational science to inform biomarker strategies from preclinical to launch, aiming to increase the probability of success and enable confident asset-related decisions. Key duties involve developing and delivering disease biomarker strategies, providing strategic translational leadership, evaluating novel technologies, and collaborating across various internal and external functions.