The Princess Máxima Imaging Center is looking for an experienced and motivated scientist with a strong background in advanced microscopy. As a key member of our state-of-the-art facility, you will take the lead in executing and advising on complex sample workflows for high-end multiplexed imaging on the MACSima™ platform (Miltenyi Biotec). You will play an active role in research projects by contributing to experimental design, data analysis, and scientific reporting, enabling researchers to map immune and tumor microenvironments using high-dimensional marker panels.

PROFILE

We are looking for an independent, detail-oriented facility scientist who thrives in a collaborative and multidisciplinary environment. You have a strong track record in advanced fluorescence microscopy and are motivated to apply your expertise to support cutting-edge research. You enjoy taking initiative, thinking critically, and contributing to scientific progress through both hands-on work and strategic input.

What you need to be successful:

• A PhD in biomedical sciences, life sciences, biochemistry, or a related field(Alternatively: at least 4 years of proven experience in a core facility or research-intensive microscopy environment)
• Extensive hands-on experience with immunofluorescence, preferably cyclic or multiplexed approaches
• Solid working knowledge of advanced fluorescence microscopy and automated imaging systems
• Experience with data analysis and scientific reporting
• Strong organizational skills and the ability to manage complex workflows independently
• Excellent communication skills and a collaborative mindset
• Experience with organoid models, clinical samples, or bioinformatics is considered a plus

The MACSima™ microscope enables cyclic immunofluorescence with over 100 markers on a single sample, offering unparalleled depth in spatial proteomics. You will be responsible for the end-to-end execution and optimization of these experiments, including sample preparation, instrument operation, data pre-processing, and scientific interpretation. You will collaborate closely with internal and external research partners, including the bioinformatics team and will contribute to the development of new projects related to advanced multiplex imaging.
In addition to your primary responsibility for MACSima workflows, you will be embedded within the Princess Máxima Imaging Center team. You will serve as a knowledge resource for your colleagues and provide expert support across the broader imaging portfolio. You will be actively involved in antibody validation, user training and technology development. With your strong scientific background and independent working style, you will play a crucial role in ensuring operational continuity, scientific excellence, and strategic development of the facility.

Responsibilities

• Lead and execute complex sample preparation and high-content multiplexed staining workflows using the MACSima™ platform
• Maintain, troubleshoot, and further develop the MACSima system and associated laboratory infrastructure
• Provide scientific and technical guidance to users and serve as a point of expertise within the Imaging Center team
• Optimize, validate, and document antibody panels for cyclic immunofluorescence across various sample types
• Analyze, interpret, and report experimental data, in collaboration with researchers and bioinformaticians
• Support users in experimental design and integration of imaging into broader research strategies
• Contribute to the implementation and validation of novel multiplex imaging technologies