Imaging Scientist III

at  Fusion Pharmaceuticals US Inc

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines.
Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to:
FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor
currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon
be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune-
oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radioconjugate manufacturing facility to
meet supply demand for our growing pipeline of RCs

SCIENTIST III, IMAGING

Fusion Pharmaceutical is seeking outstanding candidates for a Scientist III, Imaging who will provide strategic and technical expertise in the design and implementation of nuclear imaging methods applied to pre-clinical studies across therapeutic areas. The candidate will work collaboratively with internal research teams to integrate and support the application of imaging towards RC development. This position is based at Fusion’s laboratories in Hamilton, Ontario, Canada.

Responsibilities:

• As leader of Fusion’s Imaging Team within the Discovery Group, develop and expand internal preclinical imaging capabilities and spearhead the incorporation of nuclear imaging modalities into Fusion’s Discovery experimental workflow
• Design and conduct imaging-based biodistribution studies of radiopharmaceuticals in rodent models of cancer (or other disease indications of interest). Perform reconstruction and quantification of multimodal imaging data.
• Mentor and train direct reports. Support Fusion’s scientific staff by providing training and guidance towards planning, performing, and troubleshooting imaging studies
• As part of Fusion’s Discovery group, work with cross-functional experts to develop and implement imaging-based methods to explore dosimetry and PK/PD relationships as they relate to mechanism of action across our therapeutic pipeline
• Liaise with the Clinical Medical Imaging team to align nuclear medicine imaging protocols, including review of parameters for QC, image acquisition and reconstruction, radiation dose determination, and protocol dose management.
• Oversee the maintenance, calibration, and operation of state-of-the-art PET/SPECT/CT/MRI/Optical imaging equipment
• Produce high quality and well documented data with strong attention to detail
• Contribute to internal project teams through the setting and achievement of scientific goals, communication of results, and solving multifaceted scientific challenges
• Other duties as required

Qualifications:

• Ph. D (Biochemistry, Biology, Immunology, Biomedical Engineering, Medical physics, Molecular/Cell Biology or related field) with at least 3 years of post-graduate experience and a minimum of 7 years of molecular imaging experience. Biotech or pharmaceutical experience is an asset.
• Experience with development and technical validation of in vivo nuclear (PET/SPECT/CT/MRI) imaging methods and protocols.
• Experience with in vivo disease models in rodents, oncology experience is an asset.
• Expertise with the operation of nuclear imaging equipment including software image reconstruction, analysis, and quantification of nuclear imaging data.
• Ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment.
• Solution-oriented and effective team player in a multi-disciplinary setting, with the ability to communicate with colleagues at all levels.
• Experience with the safe handling of radioactive and potentially biohazardous materials.
• Experience in people management is an asset.

Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran

• As leader of Fusion’s Imaging Team within the Discovery Group, develop and expand internal preclinical imaging capabilities and spearhead the incorporation of nuclear imaging modalities into Fusion’s Discovery experimental workflow
• Design and conduct imaging-based biodistribution studies of radiopharmaceuticals in rodent models of cancer (or other disease indications of interest). Perform reconstruction and quantification of multimodal imaging data.
• Mentor and train direct reports. Support Fusion’s scientific staff by providing training and guidance towards planning, performing, and troubleshooting imaging studies
• As part of Fusion’s Discovery group, work with cross-functional experts to develop and implement imaging-based methods to explore dosimetry and PK/PD relationships as they relate to mechanism of action across our therapeutic pipeline
• Liaise with the Clinical Medical Imaging team to align nuclear medicine imaging protocols, including review of parameters for QC, image acquisition and reconstruction, radiation dose determination, and protocol dose management.
• Oversee the maintenance, calibration, and operation of state-of-the-art PET/SPECT/CT/MRI/Optical imaging equipment
• Produce high quality and well documented data with strong attention to detail
• Contribute to internal project teams through the setting and achievement of scientific goals, communication of results, and solving multifaceted scientific challenges
• Other duties as require