ProQR Therapeutics is a NASDAQ-listed biotechnology company headquartered in Leiden, the Netherlands, with an office in Cambridge, Massachusetts, USA. At ProQR, we are on a mission to edit RNA, treat disease, and change lives. A team of 180+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is committed to pioneering transformative RNA therapies to make a difference in the lives of the communities we serve.
Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cell’s own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), a protein that is present in all human cells, to repair G-to-A mutations, modulate protein expression, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases. By harnessing the power of RNA editing, we aim to create a world where genetics informs your health - but never limits it.
ProQR is currently looking for an IT Operations Manager (full-time) to join our IT department, reporting to the CPOO.
Location: Leiden, NL (on-site)
The role:
The IT Operations Manager oversees and manages critical IT functions, supports the business, and is involved in IT SOX-related matters, including internal and external audits. In addition, the IT Operations and Compliance Manager also directs and mentors the IT Operations and Compliance Specialist, ensuring alignment with operational goals, regulatory requirements, and continuous improvement initiatives.
This role is responsible for the day-to-day needs of the business and translates those business needs into a friendly and positive user experience during the entire IT journey of ProQR users.

Key duties and responsibilities:

• Manage Outsourced IT Services and SLAs: Serve as the primary liaison for outsourced IT service providers, overseeing their performance to ensure prompt and effective delivery of IT infrastructure, networking, and cloud services. In addition, establish, monitor, and enforce Service Level Agreements (SLAs) to maintain high standards of service, track compliance, and drive continuous improvement in collaboration with external partners.
• User Support and Troubleshooting: Provide hands-on support to employees across all departments, addressing a wide range of IT-related issues, with a particular focus on the Microsoft ecosystem, including M365 environment, Office applications, and other Microsoft- and non-Microsoft-based solutions
• Maintain a SOX-compliant IT environment: Safeguard the company’s Sarbanes-Oxley (SOX) compliance by managing and enforcing daily, monthly, quarterly, and annual key IT controls. Ensure that all IT operations align with regulatory requirements and internal control frameworks. This includes delegating tasks, providing guidance on compliance protocols, and overseeing the IT Operations and Compliance Specialist’s contributions to audit readiness and IT service delivery.
• Plan and manage implementations, changes, and incidents, including the ERP systems (SAP & Basware), and the IT Service Management tool 4me
• Communicate with internal and external parties.
• Information Security Oversight: overseeing and monitoring information security issues within the organization. This entails close collaboration with the Information Security Officer (ISO) and Data Protection Officer (DPO) to ensure all IT operations comply with established security protocols and regulatory requirements. Together, they proactively address emerging information security risks and safeguard company data and systems.

Required qualifications:

• A highly motivated, user-focused, accountable team player with excellent interpersonal, diplomatic, written, and oral communication skills, who is able to build relationships at all levels of the organization
• Excellent problem-solving skills and the ability to provide high-quality IT user support
• Knowledge of IT risk management, cybersecurity best practices, and incident response
• Minimal BSc degree or BBA degree or equivalent with IT / technical affinity, min of 5 years of experience in IT
• Excellent command of spoken and written English
• Able to work under pressure

ProQR as an employer

As an employer, we value a diverse workforce in which people are encouraged to develop themselves both personally and professionally. We believe that when people are happy, energized, and supported by an environment in which they can thrive, they can achieve extraordinary things. We are committed to ensuring that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage or civil partnership status. At ProQR, we want to create an inclusive culture where everyone can be valued for who they are, and in which individual differences and contributions in all forms are recognized and valued. We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

• 8% holiday allowance
• 30 vacation days
• An annual performance bonus
• Stock options
• A premium-free pension plan
• A commuting allowance
• A subsidized staff restaurant
• Unlimited (un)healthy snacks and drinks
• Employee events (boot camp, Coffee and Collaboration Café, and other social events)

We are looking for people who are inspired by our mission to edit RNA, treat disease, and change lives. Are you up for the challenge? Submit your application via the Apply button below.
Please contact Silvia Catellani at recruitment@proqr.com if you have any questions.

LI-SC

• Manage Outsourced IT Services and SLAs: Serve as the primary liaison for outsourced IT service providers, overseeing their performance to ensure prompt and effective delivery of IT infrastructure, networking, and cloud services. In addition, establish, monitor, and enforce Service Level Agreements (SLAs) to maintain high standards of service, track compliance, and drive continuous improvement in collaboration with external partners.
• User Support and Troubleshooting: Provide hands-on support to employees across all departments, addressing a wide range of IT-related issues, with a particular focus on the Microsoft ecosystem, including M365 environment, Office applications, and other Microsoft- and non-Microsoft-based solutions
• Maintain a SOX-compliant IT environment: Safeguard the company’s Sarbanes-Oxley (SOX) compliance by managing and enforcing daily, monthly, quarterly, and annual key IT controls. Ensure that all IT operations align with regulatory requirements and internal control frameworks. This includes delegating tasks, providing guidance on compliance protocols, and overseeing the IT Operations and Compliance Specialist’s contributions to audit readiness and IT service delivery.
• Plan and manage implementations, changes, and incidents, including the ERP systems (SAP & Basware), and the IT Service Management tool 4me
• Communicate with internal and external parties.
• Information Security Oversight: overseeing and monitoring information security issues within the organization. This entails close collaboration with the Information Security Officer (ISO) and Data Protection Officer (DPO) to ensure all IT operations comply with established security protocols and regulatory requirements. Together, they proactively address emerging information security risks and safeguard company data and systems