Manager, Patient Cell Operations at Lyell Immunopharma

Bothell, Washington, United States -

Full Time

Start Date

Immediate

Expiry Date

24 Mar, 26

Salary

170000.0

Posted On

24 Dec, 25

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Patient Cell Operations, Apheresis Collection, Drug Product Administration, Cross-Functional Collaboration, Process Improvement, Training Development, Regulatory Compliance, Quality Management, Clinical Operations, Supplier Management, Documentation Review, Operational Excellence, CAPA Management, Team Leadership, Dynamic Environment Adaptability, Detail Orientation

Industry

Biotechnology Research

Description

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response. We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency. Position Summary The Manager, Patient Cell Operations is a key member of the Patient Cell Supply Chain team within the Supply Chain organization. This role is responsible for the operational oversight and management of patient cells throughout the cell-therapy lifecycle, including apheresis, tissue collection, and final drug product handling. This highly cross-functional role partners closely with Manufacturing, Clinical Operations, Quality, and external clinical sites and apheresis centers to ensure right-first-time execution of patient cell handling processes that support manufacturing and clinical trial success. To be successful in this role, the individual must be self-motivated, detail-oriented, and capable of operating effectively in a dynamic environment. In addition to supporting day-to-day patient cell handling during collections and drug product receipt and administration, this role requires forward-thinking leadership to establish scalable processes, procedures, and training frameworks and to support the future growth of the Patient Cell Operations team. Key Roles and Responsibilities Patient Cell Operations Execution Create, manage, and maintain controlled manuals describing processes for apheresis collection and final drug product administration. Ensure right-first-time apheresis and final drug product handling at clinical sites and apheresis centers. Manage relationships with Lyell healthy donor apheresis suppliers. Own and manage CAPAs and deviations related to improper handling of patient cells. Partner cross-functionally with Manufacturing, Quality, Clinical Operations, and external vendors and service providers. Ensure materials and shipping containers required for patient cell collection, transport, and final drug product handling are properly validated. Establish and continuously improve electronic tools, processes, and procedures to support Patient Cell Operations activities. Clinical Site Readiness & Training Lead the oversight and execution of training for clinical sites and apheresis centers on the Apheresis Manual and Drug Product Administration Manual, ensuring procedural compliance and operational excellence. Develop, deliver, and routinely update training programs to reflect evolving operational practices, regulatory requirements, and feedback from clinical and apheresis sites. Support clinical site onboarding and requalification through structured training, documentation review, mock runs, and site readiness assessments. Ensure all personnel involved in patient cell handling are appropriately trained, qualified, and documented in accordance with GxP requirements. Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents. The salary range for this position is $150,000 to $170,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan. Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws. We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

Responsibilities

The Manager, Patient Cell Operations oversees the operational management of patient cells throughout the cell-therapy lifecycle. This includes ensuring compliance with handling processes and managing relationships with external suppliers.