Medical Director, Clinical Development, Oncology at Pathos

New York, New York, United States -

Full Time

Start Date

Immediate

Expiry Date

26 Aug, 26

Salary

320000.0

Posted On

28 May, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Clinical Trial Design, Medical Monitoring, Oncology Clinical Development, Protocol Drafting, Patient Safety, Biomarker Study Design, Regulatory Authoring, Cross-functional Leadership, GCP Compliance, KOL Relationship Management, AI Tool Integration, Clinical Strategy, Data Analysis, Medical Review, Patient Selection Strategies, Clinical Development Planning

Industry

Biotechnology Research

Description

About the Role The Medical Director is a member of the Clinical Development team, accountable for the design, execution, oversight, and analysis of Pathos clinical trials. You will translate the predictions of the Oncology Foundation Model into protocols that ask the right scientific questions of the right patients, and you will own medical monitoring, site interactions, and clinical strategy across the portfolio. You will work closely with R&D, Translational Medicine, Biomarker, and other internal teams to embed the right biomarker studies into every protocol and to correlate clinical and translational findings into the next development decision. You will partner daily with each asset team to shape clinical strategy and provide medical and scientific judgment to the rest of the company as a working leader. You will report to the Chief Development Lead. This role sits at the intersection of deep oncology medicine and an AI native operating model. You will spend less time chasing processes and more time on the medical questions that move programs forward, because Foundry and a fleet of AI agents absorb the document drafting, data triage, literature surveillance, and coordination work that traditionally consumed a Medical Director's calendar. What You Will Do Own medical monitoring and patient safety Lead medical review of trial data, including ongoing eligibility, protocol deviations, and safety signals. Assess key safety-related serious adverse events, approve safety narratives, and direct site education on safety management. Serve as the medical point of contact for clinical sites, addressing investigator questions and supporting enrollment quality. Use Foundry to surface live enrollment, safety, and biomarker signals across active studies, and direct AI agents to draft narratives, summaries, and data clean-up actions for your review. Drive clinical strategy and protocol design Draft clinical protocols alongside Clinical Operations and Medical Writing colleagues, owning study design, target patient population, eligibility criteria, and safety risk mitigation. Translate Oncology Foundation Model predictions, scenario analyses, and real-world evidence into clinical strategies that increase the probability of success for each asset. Contribute to the Clinical Development Plan for each Pathos program, anchoring strategy in the molecular and clinical biology of the indication. Execute trials with discipline Provide oversight and medical accountability across active studies. Adjudicate protocol violations, validate medical data, and serve as the medical resource for site staff. Support executional delivery from site activation through enrollment to closeout, working in concert with Clinical Operations and AI agents that absorb status tracking, document version control, and coordination tasks. Fulfill GCP and compliance obligations, maintaining required training and audit-ready trial conduct. Author regulatory and scientific content Author clinical content for CSRs, regulatory reports, briefing books, and submission documents in partnership with Clinical Operations and Medical Writing. Interact with Health Authorities, IRBs, and Ethics Committees as the Clinical Program Lead. Direct AI agents to compile, structure, and quality check submission packages, then apply your medical judgment to the final product. Build external scientific presence Identify and build relationships with principal investigators and KOLs in our target modalities and indications. Stay current on competitive compounds, regulatory shifts, and novel trial designs, and convert that intelligence into recommendations for Pathos strategy. Maintain a clinical and scientific reputation in the diseases and modalities relevant to the Pathos portfolio. Who You Are Minimum Qualifications MD required, or US equivalent. 2 or more years of biotech or pharma industry experience in oncology clinical trial development and execution, preferably in solid tumors across Phase I, II, and III. Track record of delivering effective clinical trial plans and protocols within the drug development process. Leadership and mentorship instincts, with a hands-on, working-leader approach. Demonstrated ability to lead teams cross-functionally. Ability to travel up to 30%, domestic and international. Experience designing biomarker driven trials and partnering closely with Translational Medicine and Biomarker teams. Comfort interpreting AI-generated predictions, scenario analyses, and real world evidence, and folding them into trial design decisions. Experience operating in a flat, builder oriented organization where you specify, orchestrate, and ship rather than manage process. Nice to Have Specialty training in Medical Oncology. Direct experience with patient selection strategies grounded in molecular or computational evidence. Experience using AI tools or agentic workflows to accelerate medical monitoring, protocol drafting, or regulatory authoring. Prior leadership of cross functional asset teams from candidate selection through clinical readout. Location The preferred location for this position is in our New York City HQ, though exceptional remote candidates will also be considered.

Responsibilities

The Medical Director is responsible for the design, execution, and medical oversight of oncology clinical trials, translating AI predictions into scientific protocols. They will lead medical monitoring, manage site interactions, and collaborate cross-functionally to drive clinical strategy and regulatory submissions.