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Modular phage-based nanocarriers for radioligand therapy at centredtud
, , Belgium -
Full Time

Start Date

Immediate

Expiry Date

21 Mar, 26

Salary

0.0

Posted On

21 Dec, 25

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

No

Skills

Genetic Engineering, Chemical Bioconjugation, Radiochemistry, Tumor Targeting, Modular Design, Phage Production, Preclinical Validation, Radioligand Therapy, Nanocarriers, Cancer Research, Biocompatibility, Drug Delivery, Programmable Carriers, Radionuclide Decay, Cytotoxic Eradication, Precision Oncology

Industry

Research Services

Description
This PhD project aims to develop modular bacteriophage-based nanocarriers for targeted radioligand therapy (RLT), which constitutes a cornerstone of modern precision oncology, employing ionizing radiation emitted from radionuclide decay to selectively damage tumor cell DNA and achieve cytotoxic eradication. Cancer remains a global health challenge and currently available delivery systems often suffer from limited specificity and off-target toxicity. Engineered bacteriophages, viruses that infect bacteria, offer unique advantages for drug and radionuclide delivery due to their biocompatibility, structural regularity and capacity for precise genetic modification. By integrating tumor-targeting ligands, radiometal chelators and bio-orthogonal functional groups, phages can be transformed into modular, programmable carriers for radiotherapeutic payloads. The project combines modern genetic engineering, chemical bioconjugation and radiochemistry tools to rigorously evaluate the therapeutic potential of phage-based vectors. Over the four-year timeline, the research will advance from molecular design and phage production to preclinical validation in relevant tumor models. The work will accelerate the development and availability of life-saving nuclear therapies and will contribute to driving cancer research and care forward in a powerful way.
Responsibilities
The PhD project involves developing modular bacteriophage-based nanocarriers for targeted radioligand therapy. The research will progress from molecular design and phage production to preclinical validation in relevant tumor models over a four-year timeline.