Organoid R&D Scientist & Manager at ACROBIOSYSTEMS INC

Beijing, Beijing, China -

Full Time

Start Date

Immediate

Expiry Date

23 Jun, 26

Salary

0.0

Posted On

25 Mar, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

iPSC Culture, Organoid Development, Differentiation Protocols, CRISPR/Cas9, Functional Assays, Molecular Biology, Cell Biology, Data Analysis, Project Management, Drug Screening, Toxicity Testing, SOP Drafting, Immunocytochemistry, Electrophysiology, Metabolic Function Assays, Flow Cytometry

Industry

Biotechnology Research

Description

Organoid R&D Scientist & Manager We are a global leader in life sciences tools, working with all top 50 biopharma, 10,000+ institutions across the world, with a big emphasis on stem cell and organoid technology, building iPSC-derived 2D and 3D models to accelerate drug discovery (toxicity & efficacy screening). We are seeking passionate and innovative Organoid R&D scientists to architect our core technology platform and translate groundbreaking science into transformative applications. In this high-impact role, you will go beyond standard protocols to create robust, physiologically relevant, and scalable human models that will power global drug discovery pipelines. We aim to increase preclinical translatability and decrease current clinical failure rate. You will receive support from the corporation and get to enjoy being part of a startup-like fast-moving team. Responsibilities 1. Design and develop efficient protocols for directing the differentiation of iPSCs into organoids and specific cell types (e.g., liver, cardiac, skin, kidney, neural, etc.). 2. Lead research in the establishment, optimization, functional maturation, and improvement of batch-to-batch consistency for iPSC-based 2D differentiation models and 3D organoids. 3. Utilize gene-editing technologies (e.g., CRISPR/Cas9) to construct disease models in iPSCs for mechanism research and drug screening. 4. Employ a comprehensive range of molecular biology, cell biology, and functional analysis techniques (e.g., qPCR, immunocytochemistry, electrophysiology, metabolic function assays) to thoroughly characterize differentiated cells and organoids. 5. Independently analyze and interpret complex experimental data; draft Standard Operating Procedures (SOPs), technical reports, and research summaries to ensure traceability and compliance of R&D activities. 6. Collaborate closely with pharmacology and genomics teams to apply established iPSC models to high-throughput drug screening and toxicity testing. 7. Stay abreast of the latest technological advancements in the field and provide insights to inform the company's technology strategy and innovation. Qualifications 1. Ph.D. or post doc in Cell Biology, Developmental Biology, Stem Cells, or a related field;. Work or internship experience is a plus. 2. Strong analytical mindset and extensive hands-on experience in iPSC culture, passaging, cryopreservation, assays, and developing novel differentiation protocols 3. Demonstrated successful experience in directing the differentiation of iPSCs into at least one specific cell lineage (e.g., CNS, midgut, liver, pancreas, kidney, vascular endothelium, immune cells). 4. Proficient in cellular and molecular biology techniques (immunofluorescence, flow cytometry, Western Blot, qPCR, etc.). 5. Excellent data analysis, problem-solving, and project management skills. Meticulous work ethic with a high sense of responsibility, innovative thinking, and strong team collaboration spirit. Preferred Additional Qualifications: 1. Experience/understanding of preclinical drug safety evaluation or toxicology/pharmacology analysis. 2. Capability in functional assays. 3. Bioinformatics skills, with the ability to analyze omics data such as RNA-seq. 4. Publication record of relevant academic papers in high-impact journals Location: Beijing, China

Responsibilities

The role involves designing and developing efficient protocols for directing iPSC differentiation into various organoids and specific cell types, while leading research to optimize the establishment, functional maturation, and consistency of these 2D and 3D models. Responsibilities also include utilizing gene-editing technologies to construct disease models and applying established models to high-throughput drug screening and toxicity testing.