Cogent Scientific, an insourced contract research organization, is looking for the right people to accomplish our Mission: to partner in the global effort to improve lives through innovative science with an experienced workforce. We can offer you the chance to build on your skills and knowledge while working among experts in their fields and with cutting-edge instrumentation. Cogent Scientific offers competitive pay, attractive benefits, and an exciting work environment. We aim to recruit the best people who stand out among their peers and embody our Core Values:
Client Focused: We only succeed when our clients succeed.
Outstanding: We deliver meticulous results through outstanding performance.
Good: We act ethically and morally.
Employee-Centric: We honor and support our employees.
Nimble: We are prepared to adapt in an ever-changing industry.
Team-Oriented: We collaborate with each other and with our clients.
We currently have a role available for a Phage Display Scientist.

Job duties include, but are not limited to:

• Execute phage panning campaigns against a range of protein targets, including challenging and conformationally dynamic antigens; design and construct immune phage display libraries from Llama and bovine samples.
• Proven expertise in phage display, including library construction, panning, and binder screening
• Experience displaying peptides, antibodies, Fab, and/or Fv are preferrable.
• Proficient in phage ELISA and binding validation techniques; perform phage ELISA and related binding assays to screen and validate hits.
• Analyze sequencing data from enriched libraries to identify high-affinity and/or conformationally selective binders.
• Familiarity with next-generation sequencing (NGS) analysis of phage libraries is preferred but experience of Sanger sequencing may suffice.
• Optimize selection strategies to enrich for binders with desired biophysical or functional properties.
• Experience with BLI (Octet) or SPR for affinity and kinetics characterization; background in antibody or VHH engineering and downstream development; and experience in working with diverse target classes, including membrane proteins or conformational epitopes, are all desirable.

• Contribute to innovation efforts in library design, selection methodology, and downstream screening technologies.

• • Solid molecular biology skills, including cloning, mutagenesis, and construct design is a must
• Strong experience with immune and/or naïve antibody or peptide libraries would be advantageous.
• Maintain accurate records of experimental design, results, and interpretations in electronic lab notebooks.

Job requirements include, but are not limited to:

• M.S. or PhD with 3+ years of relevant experience; industrial experience would be advantageous.
• Thorough understanding of the theory of above-mentioned techniques.
• Team player mentality with strong written and verbal communication skills. Will be required to work collaboratively with cross-functional teams including structural biology, molecular biology, biochemistry, and biophysics.
• The ideal candidate will be enthusiastic and self-motivated, with the leadership and communication skills necessary to operate effectively in a fast-paced multidisciplinary environment with flexibility and an adaptable approach to goal delivery.

• Execute phage panning campaigns against a range of protein targets, including challenging and conformationally dynamic antigens; design and construct immune phage display libraries from Llama and bovine samples.
• Proven expertise in phage display, including library construction, panning, and binder screening
• Experience displaying peptides, antibodies, Fab, and/or Fv are preferrable.
• Proficient in phage ELISA and binding validation techniques; perform phage ELISA and related binding assays to screen and validate hits.
• Analyze sequencing data from enriched libraries to identify high-affinity and/or conformationally selective binders.
• Familiarity with next-generation sequencing (NGS) analysis of phage libraries is preferred but experience of Sanger sequencing may suffice.
• Optimize selection strategies to enrich for binders with desired biophysical or functional properties.
• Experience with BLI (Octet) or SPR for affinity and kinetics characterization; background in antibody or VHH engineering and downstream development; and experience in working with diverse target classes, including membrane proteins or conformational epitopes, are all desirable.
• Contribute to innovation efforts in library design, selection methodology, and downstream screening technologies