3 years Primary cilia are microtubule-based projections found on the surface of nearly every cell in our body. We know that humans critically depend on cilia to see, hear, smell, breathe, excrete and reproduce. Such activities require a high degree of regulation and critical feedback to ensure robustness in development and homeostasis of different cells, tissues and organs. Dysfunction of cilia causes a broad spectrum of hereditary diseases, but the molecular basis of the phenotypic diversity remains largely unknown. Understanding this multi-level organisation and regulation in health and disease requires integration of unique multidisciplinary expertise.
A consortium of nine different groups from six different European countries have successfully applied for a Marie Sklodowska Curie Action Doctoral Network, coined Cilia-AI. This Cutting-Edge Research and Training Programme will apply machine learning to understand genotype to phenotype relationships in ciliopathies.
The position in my group will focus on unravelling moonlighting functions of ciliary proteins. As a PhD candidate you will be hosted within the Radboudumc, but, given the nature of the training network, receive a lot of training throughout the different participating institutes. In addition, candidates should perform two secondments (each two to three months) within different partners lab, in order to maximize exchange and cooperation between the different groups.

Tasks and reponsibilities

• Plan and perform scientific in vitro and in vivo experiments in an independent manner.
• Critically analyze data.
• Take a leading role in writing manuscripts.
• Present data at local, national and international scientific meetings.
• Supervise MSc and/or BSc students.

Starting date as soon as possible. The applicant — at the date of recruitment — should not have resided in the country where the research training takes place for more than 12 months in the 3 years immediately prior to recruitment, and not have carried out their main activity (work, studies, etc.) in that country. At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.017 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.824 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• 176 vacation hours per year based on a 36-hour working week.

The PhD candidate will be positioned within the Center for Molecular Biomolecular Informatics, led by prof Huijnen, that focuses on using genomic data to gain a better understanding of the functions of proteins, predict how proteins interact within the human cell, and how the malfunctioning of those proteins can lead to diseases.
The Department of Medical BioSciences of the Radboudumc in Nijmegen is renowned for its basic and translational research in the medical biosciences, from molecules to humans, to better understand disease and health and improve diagnostics and treatment. The Department offers an exciting working environment with enthusiastic people from many parts of the world, providing ample critical mass and a stimulating, collaborative atmosphere for high quality research.

• Plan and perform scientific in vitro and in vivo experiments in an independent manner.
• Critically analyze data.
• Take a leading role in writing manuscripts.
• Present data at local, national and international scientific meetings.
• Supervise MSc and/or BSc students