3 years, with potential for 1 year prolongation Tuberculosis (TB) is the world’s leading infectious disease killer. Each year over 10 million persons fall ill with TB, of whom 1.5 million die. There is an urgent need for new effective and safe drugs to treat this disease. However, the development and evaluation of these drugs is very complex and requires motivated researchers to tackle this challenge. Are you the motivated PhD candidate we’re looking for? We look forward to getting to know you!
At the Radoudumc (Nijmegen, The Netherlands) we specialize in the design, execution and analysis of large scale international clinical trials for TB treatment. This position is embedded in the international UNITE4TB research consortium. You will be part of the Pharmacology and Pharmacogenomics work package and support development of novel anti-TB drug regimens through application of pharmacometric modelling.
You will contribute to the pharmacokinetic components of ongoing clinicals studies of novel anti-TB regimens by training and supporting the clinical teams at sites in multiple countries. Furthermore, you will lead clinical data analysis and develop population pharmacokinetic models, evaluate drug-drug interactions and perform exposure-response analyses on data from phase II clinical trials of novel anti-TB regimens. The project has large potential to contribute meaningfully to the fight against TB.

Tasks

• Develop and evaluate pharmacokinetic-pharmacodynamic models.
• Critically analyze data/results.
• Write manuscripts.
• Design follow-up studies.
• Supervise students.
• Present results at international conferences.
• Attend and provide training.

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€ 3.108 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3.939 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• 176 vacation hours per year based on a 36-hour working week.

The Department of Pharmacy, Pharmacology and Toxicology at Radboudumc is hosting a vibrant and successful researcher community. The position will be embedded in the research group ‘Pharmacology of anti-tuberculosis drugs’, led by prof. Rob Aarnoutse and in the ‘Radboud Applied Pharmacometrics group’, in close collaboration with Uppsala University (prof. Elin Svensson).
Radboudumc is globally known as a center of expertise on the treatment of tuberculosis (TB). We host a dedicated research program into optimizing the treatment of mycobacterial diseases with the specific aims to develop, redevelop or repurpose drugs to optimize the outcomes of mycobacterial diseases. Research is performed to personalize the treatment and there is a focus on educating talented young researchers to make meaningful impact.
The ‘Radboud Applied Pharmacometrics group’ is highly specialized in using model informed drug development. Using cutting-edge approaches, we aim to design and analyze the results from clinical trials to maximize the impact of the data gathered. In close collaboration with the Uppsala Pharmacometrics department, a world-renowned institute for pharmacometrics, we aim to improve TB treatment.

• Develop and evaluate pharmacokinetic-pharmacodynamic models.
• Critically analyze data/results.
• Write manuscripts.
• Design follow-up studies.
• Supervise students.
• Present results at international conferences.
• Attend and provide training