PhD on Cell-based Models for Recreating the Human Placenta
at TU Eindhoven
Eindhoven, Noord-Brabant, Netherlands -
Start Date | Expiry Date | Salary | Posted On | Experience | Skills | Telecommute | Sponsor Visa |
---|---|---|---|---|---|---|---|
Immediate | 22 Jan, 2025 | Not Specified | 23 Oct, 2024 | N/A | Biomedical Engineering,Independent Thinking,Biomedical Sciences,English,Tissue Culture | No | No |
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Description:
JOB DESCRIPTION
The Eindhoven University of Technology (TU/e) is seeking a highly-talented, ambitious and passionate PhD candidate to investigate the interplay between the human placenta and its environment. In particular, we aim to deploy and improve living cell models, as well as computational models, to recreate the placenta and its interaction with blood vessels, the extracellular matrix and the immune system (the fetal-maternal interface).
As the successful candidate, research that you will carry out with us will be part of wider efforts aiming at tissue-engineering the placenta for pharmacological and biological purposes, and work towards developing testing platforms for placental therapy to cure diseases of the placenta e.g. fetal growth restriction and pre-eclampsia (dangerously high blood pressure of pregnancy).
JOB DESCRIPTION
You will generate living cell, experimental, and numerical models that mimic and simulate placental function, both mechanically, as well as biologically, and solve critical questions in placental biology and disease-modelling relevant to humans.
Your research will resort to correlating experimental models combining various technologies to study the interactions between placental trophoblast cells and organoids, vascular endothelial cells, immune cells and the extracellular matrix (ECM) in a controlled micro-environment including i) stem cell culture, human tissue and bioreactor work, ii) molecular multi- omics and imaging techniques to study cells, matrix and pathways, iii) advanced immune-engineering and microfluidics work to study cell-cell interactions.
By building on experimental protocols previously established in the group, you will develop new methodological approaches and experimental setups currently unavailable in the field. You are expected to do scientific research in the field described above, write a doctoral thesis, and publish research results in scientific journals. A small part of your doctoral position will involve teaching in courses as well as the supervision of students at the bachelor’s and master’s levels offered by the group. Further, your work will include frequent interactions with our other mechanobiology groups and our clinical team at Maxima Medical Center, Veldhoven. Also, an educational and professional development program will be offered to you.
JOB REQUIREMENTS
- A master’s degree (or an equivalent university degree) in Biomedical Engineering, Biomedical Sciences, Materials Sciences, or comparable discipline.
- Extensive eperience with cell and tissue culture as well as cell-cell signaling pathway manipulation is a must. Competencies with extracellular matrix biology and cellular mechanobiology will be considered as a relevant added value.
- A research-oriented attitude.
- Ability to effectively communicate scientific ideas, foster collaborations and have a capability for independent thinking.
- Ability to work independently within a multidisciplinary team with researchers at various academic levels.
- Fluent in spoken and written English (C1 level).
ABOUT US
TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. Fundamental knowledge enables us to design solutions for the highly complex problems of today and tomorrow. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
The Department of Biomedical Engineering (BME) offers a research-driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and nontenured employees.
Responsibilities:
Please refer the Job description for details
REQUIREMENT SUMMARY
Min:N/AMax:5.0 year(s)
Hospital/Health Care
Pharma / Biotech / Healthcare / Medical / R&D
Health Care
Graduate
Biomedical engineering biomedical sciences materials sciences or comparable discipline
Proficient
1
Eindhoven, Netherlands