Im UKB werden pro Jahr etwa 500.000 Patientinnen betreut, es sind ca. 9.000 Mitarbeiterinnen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter den Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf.
Wissenschaft und Forschung
Teilzeit
PhD position – Metabolic regulation of tissue-resident immune cells during metastasis – Institute of Clinical Chemistry and Clinical Pharmacology
ST-17023
The Tumor Immunometabolism research group led by Jun. Prof. Laura Surace at the Institute of Clinical Chemistry and Clinical Pharmacology (University Hospital Bonn Campus), Faculty of Medicine Rheinische Friedrich Wilhelms-University Bonn
invites applications for part-time (25,025h/week)
PhD position – Metabolic regulation of tissue-resident immune cells during metastasis
We are seeking highly motivated candidates with a strong interest in immunology. Our lab is interested in better understanding the role of tissue-resident immune cells in metastasis formation. We aim to achieve this by defining tissue-specific immune subset metabolic requirements, phenotype and function and by assessing their interplay with the other components of the primary tumor and metastasis microenvironment. We specifically focus on innate lymphoid cells (ILC) and T cells (Karagiannis F, Peukert K, Surace L*, et al. Nature 2022; Surace et al. Nature Immunology 2021; Surace et al. Blood Advances 2021). For more information, please refer to the website à https://www.ukbonn.de/ikckp/forschung/ag–surace/. The project will investigate how changes in host metabolism shape the cellular composition and the metabolic features of the tissue microenvironment, during tumor development and metastasis. Ultimately the goal is to identify novel therapeutic strategies, including dietary intervention, that would be applicable in the treatment of metastatic cancer.

REQUIREMENTS:

Master’s degree in life science (biology, biomedicine, molecular medicine or comparable studies).
Candidates with experience in immunology, molecular or cell biology and biochemistry are specifically encouraged to apply
Experience in laboratory techniques and the use of experimental mouse models
Ability to work independently and in a team
English skills
The candidate will work with mouse models and human samples applying classical immunological methods alongside cutting-edge technologies, including imaging mass spectrometry, multiplex tissue imaging, metabolomics and extracellular flux analysis. The selected candidate will have access to scientific and soft skill training through courses provided by the University of Bonn and external institutions.

Please refer the Job description for details