PhD student (m/f/d) at Robert Bosch Krankenhaus GmbH

Stuttgart, Baden-Württemberg, Germany -

Full Time

Start Date

Immediate

Expiry Date

08 Apr, 26

Salary

0.0

Posted On

08 Jan, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Bioinformatics, Data Analysis, Cancer Biology, Programming Skills, R, Python, Biostatistics, Multi-Omics Data Analysis, Single-Cell RNA Sequencing, Spatial Transcriptomics, Genomics, Metabolomics, Data Integration, Clinical Phenotypes, Oncology, Personalized Medicine

Industry

Hospitals and Health Care

Description

Company Description The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director Prof. Dr. M. Schwab) is operated by the Robert Bosch Stiftung. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned scientific research unit in the field of clinical pharmacology. Main research activities concentrate on the influence of genetic and non-genetic factors on variability of drug efficacy and their contributions to disease development. For a graduate program focusing on “Non-canonical G protein signaling: Mechanism, Functions, Consequences”. The PhD project will address various aspects of cancer therapy and tumor cell biology through -omics data analysis. The project will be closely linked to clinical aspects of cancer research. Job Description Bioinformatic analysis of multi-omics data to elucidate the role of nucleoside diphosphate kinases (NDPK) in the tumor microenvironment and their potential influence on cancer progression and metastasis Characterization of primary tumors and metastasis using multi-omics data sets (e.g. genomics, metabolomics) with focus on single-cell and spatial transcriptomics RNA sequencing data Integrated analysis of clinical phenotypes and -omics data using biostatistics and bioinformatics Application of a broad spectrum of established and new bioinformatics analysis strategies with focus on single-cell and spatial transcriptomics RNA seq and data integration Capacity and enthusiasm to undertake the training activities of a graduate program supported by programs of the Faculty of Medicine and the Graduate Academy of the University of Tuebingen to ensure greatest possible success in your career track Qualifications Master degree (M.Sc.) in bioinformatics, applied bioinformatics or a related discipline Experience and strong background in the analysis of bulk and single-cell RNA sequencing data and data interpretation Experience in the analysis of multi-omics datasets (e.g. proteomics, transcriptomics, genomics) Strong programming skills in R, and preferably in Python Solid background in cancer biology Good knowledge in biostatistics would be beneficial Interest in oncology and personalized medicine Excellent English written and oral communication skills Additional Information We offer: The opportunity to work in an interactive team providing support and mentoring State-of-the-art equipment and technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities (e.g. core facility “Biostatistics/Bioinformatics, Pharmacometrics and Digital Science”) at the institute Participation in the PhD program The opportunity to communicate scientific results at international conferences and to participate in workshops A unique feature of the educational program is the co-supervision of each PhD student by a team of investigators, which contribute with their unique expertise to the progress of the projects An initial contract for 3 years and flexible starting date (earliest starting date as of now) For further information please contact Prof. Dr. Matthias Schwab (phone 0711-8101-3700) or Dr. Elke Schaeffeler (phone 0711-8101-3729). Sind Sie bereit für eine neue Herausforderung? Dann bewerben Sie sich jetzt über unser Online-Karriereportal. Die angegebenen Arbeitgeberleistungen können je nach Position und Anstellungsverhältnis variieren. Bitte beachten Sie die geltenden Nachweispflichten aufgrund des Infektionsschutzgesetzes als Einstellungsvoraussetzung. Wir schätzen die Einzigartigkeit und Unterschiedlichkeit unserer Mitarbeitenden und fördern ein Arbeitsumfeld, das unabhängig von Alter, Geschlecht, sexueller Identität, Behinderung, Herkunft oder Religion gleiche Chancen ermöglicht. Mit Einreichung Ihrer Bewerbungsunterlagen stimmen Sie zu, dass Ihre Bewerberdaten in der Bewerbermanagementsoftware SmartRecruiters aufgenommen und verarbeitet werden. Hinweise zu unserem Datenschutz finden Sie hier: Datenschutz. Tätigkeitsfeld: Wissenschaft und Forschung Beschäftigungsumfang: Vollzeit

Responsibilities

The PhD project involves bioinformatic analysis of multi-omics data to study nucleoside diphosphate kinases in the tumor microenvironment. It also includes characterizing primary tumors and metastasis using various -omics data sets.