PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scien at Takeda Pharmaceutical Company Limited USA

Fujisawa, , Japan -

Full Time

Start Date

Immediate

Expiry Date

30 Mar, 26

Salary

0.0

Posted On

30 Dec, 25

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Mathematical Modeling, Quantitative Analysis, Pharmacology, Biology, Chemistry, Drug Metabolism, Translational Medicine, Clinical Pharmacology, Cross-Functional Collaboration, Communication Skills, Analytical Skills, Modeling Tools, Neuroscience, Simulation Strategies, Decision Making, Benchmarking Insights

Industry

Pharmaceutical Manufacturing

Description

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description タケダの紹介 (Introduction of Takeda) タケダでは常に患者さんを中心に考え、世界中の人々により健やかで輝かしい未来をお届けすることを目指しています。また、タケダは業界を牽引するグローバルリーダーであり、従業員は四つの優先順位（患者さん中心、社会との信頼関係構築、レピュテーションの向上、事業の発展）とタケダイズム（誠実＝公正・正直・不屈）のもと一致団結しています。タケダイズムは私たちの信念であり正しい方向へ導く羅針盤です。私たちは日々の業務においてタケダイズムを体現しています。私たちと一緒に、世界中の人々のいのちに貢献し、さらなる成長と活躍を目指しませんか。そのようなあなたを、湘南研究所（神奈川）の「PK/PDおよびQSPモデラー（ニューロサイエンス領域）– プリンシパルサイエンティストまたはアソシエイトサイエンティスト」としてお迎えします。 Takeda is unwavering in our commitment to patients. With the patient at the center of everything we do, we continue to innovate and drive changes that will better their lives. Takeda is a global industry leader –we are united by our four priorities (Patients, Trust, Reputation, and Business) and our shared values of Takeda-ism: Integrity, Fairness, Honesty, and Perseverance. Takeda-ism is more than just a word. It’s a belief and a mindset which guides our decisions, behaviors, and interactions. It’s how we strive to work and live, every day. Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scientist in our Shonan, Kanagawa location. 目的／ミッション (Objective / Purpose) PK/PDおよびQSPモデラー（ニューロサイエンス領域）– プリンシパルサイエンティストまたはアソシエイトサイエンティストとして、DMPK & Modeling 部門の一員となり、生物学／薬理、化学／バイオロジクス、前臨床安全性評価、薬物代謝、トランスレーショナルメディシン、臨床薬理および臨床開発の各チームの橋渡し役を担っていただき、定量的数理モデルの解析を通じて、創薬の研究開発における意思決定に影響を与えることが期待されています。 As a PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scientist in DMPK & Modeling, you will be empowered to interface between biology/pharmacology, chemistry/biologics, nonclinical safety assessment, drug metabolism, translational medicine, clinical pharmacology and clinical research, to influence drug discovery and development. 職務内容 (Accountabilities) 神経変性疾患および神経筋疾患を含むさまざまな神経疾患を対象とした新規治療薬について、定量的数理モデルを構築し、創薬の研究開発における意思決定を推進します。前臨床生物学／薬理、ケミストリー／バイオロジクス、前臨床安全性評価、トランスレーショナルメディシン、臨床薬理および臨床開発などのクロスファンクショナルチームと協働し、標的とする生物学的経路と新規治療薬の相互作用、およびそれらが病態進行に与える影響について、数理モデルに基づいて理解を深めることに貢献します。チームを巻き込んだ最適なモデリング＆シミュレーション戦略を立案し、実行します。創薬候補物質の選択、試験デザインの最適化、バイオマーカー選択に関する意思決定を支援・加速するため、トランスレーショナルなPK/PD/efficacy model, mechanistic modelあるいはsystems modelを設計・構築します。臨床試験に向けて、ヒトでの薬理活性／有効用量、投与スケジュール、安全域を予測します。そのために、臨床段階の比較薬から得られるベンチマーキング情報や、それらのリバーストランスレーションから得られる知見を有効に活用します。 Drive decision-making in drug discovery and development by building a quantitative model of novel therapeutic agents to treat various neurological diseases including neurodegeneration and neuromuscular diseases. Work on cross-functional teams with preclinical biology/pharmacology, chemistry/biologics, nonclinical safety assessment, translational medicine, clinical pharmacology and clinical research to develop a quantitative model-based understanding of the interactions of target biological pathways and novel therapeutic agents, and their impact on disease progression. Formulate and implement team-engaged right modeling & simulation strategy. Design and build translational PK/PD/efficacy and mechanistic and/or systems models to assist and accelerate decisions around drug candidate selection, study design optimization as well as biomarker selection. Enable translational predictions of human pharmacologically active/efficacious dose, dosing schedule and safety margin for clinical trials. Leverage clinical benchmarking insights from clinical comparators and/or their reverse translation. 学歴・能力要件 (Education & Competencies) 化学工学／生物医学工学、製剤・薬学、数学、物理学分野などのMS／PhD／PharmDを有すること数理モデル構築の高い能力（MATLAB、SimBiology、NONMEM、Monolix、Phoenix、Python、Rなど一般的に用いられる言語／ツールのいずれかの使用経験）生体システムの数理モデルを用いた定量的解析を行った経験。特に、神経疾患領域にモデリング＆シミュレーションアプローチを適用した経験、もしくはその分野への強い関心があることが望ましい複雑な情報を解析し、重要な科学的問いを特定できる優れた分析能力複雑な数理モデル解析の結果を、クロスファンクショナルなチームメンバーに対して、分かりやすく簡潔に伝えるコミュニケーション能力グローバルチームの下で業務を推進していくための、読み書き及び会話の両面での良好なビジネス英語力（TOEICスコア750点以上など） MS/PhD/PharmD in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area. Strong competency in building mathematical models is required (in commonly used languages such as MATLAB, SimBiology, NONMEM, Monolix, Phoenix, Python, or R) Experience in mathematical modeling of biological systems. Especially, an experience and/or interest in applying modeling and simulation approaches to neurological diseases is preferred. Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions. Ability to communicate complex modeling results clearly and concisely to cross-functional audience is critical. Good English communication skill in both written and verbal (TOEIC score ≥750, etc.) to work under global team setting Takeda Compensation and Benefits Summary: Allowances: Commutation, Housing, Overtime Work etc. Salary Increase: Annually, Bonus Payment: Twice a year Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45 Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year) Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave. Flexible Work Styles: Flextime, Telework Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc. Important Notice concerning working conditions: It is possible the job scope may change at the company’s discretion. It is possible the department and workplace may change at the company’s discretion. Locations Fujisawa, Japan Worker Type Employee Worker Sub-Type Regular Time Type Full time Takeda is an industry-leading, global pharmaceutical company with an unwavering dedication to putting patients at the center of everything we do. We live our values of Takeda-ism – Integrity, Fairness, Honesty, and Perseverance – and are united by our mission to strive towards Better Health and a Brighter Future for people worldwide through leading innovation in medicine. Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. At Takeda, you will make an impact on people’s lives – including your own. Takeda is an equal opportunity employer. For applicants of U.S and Puerto Rico positions: Click here to learn about our commitment to Equal Employment Opportunity (EEO). If you are limited in the ability to use our job application tool, or otherwise require a reasonable accommodation for a disability please click here.

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Responsibilities

The role involves building quantitative models for novel therapeutic agents targeting neurological diseases and influencing drug discovery decisions. Collaboration with cross-functional teams is essential to understand the interactions of biological pathways and therapeutic agents.