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Post-Doctoral Fellow - Myosin Phosphatase at University of Maryland
Baltimore, Maryland, United States -
Full Time

Start Date

Immediate

Expiry Date

27 May, 26

Salary

0.0

Posted On

26 Feb, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

No

Skills

Cell Biology, Molecular Biology, Animal Models, Cre-Lox, AAV-Crispr/Cas9, Gene Expression, Contractility, Blood Flow Regulation, Hypertension Models, Heart Failure Models

Industry

Description
Post-doctoral research position in Division of Cardiology University of Maryland A full time Post-Doctoral fellowship position is available in the laboratory of Dr. Steven Fisher in the Division of Cardiology at the University of Maryland-Baltimore as of April 1, 2019. The federally funded project examines vascular smooth muscle gene expression and contractility in the regulation of blood flow in development and disease models. The focus is on the myosin phosphatase (MP), a critical target of signals that regulate blood flow. Experiments will test the hypothesis that editing of MP lowers blood pressure in models of hypertension and heart failure, and will determine the mechanism(s) by which it does so. The post-doc will perform experiments in animal models using Cre-Lox and AAV-Crispr/Cas9 editing of MP in vivo. The AAV-Crispr/Cas9 approach of editing is in pre-clinical development as a novel therapy for humans with hypertension and heart failure. Applicants are required to have a Ph.D. or M.D. and expertise in techniques of cell and molecular biology. Familiarity with experimental techniques required for the study of small blood vessels is preferred but not required. If interested please email a CV, a short statement of research interests, and the names and contact information for three references to: Steven Fisher, MD, Professor of Medicine and Physiology, at SFisher1@som.umaryland.edu . Applicants are required to have a Ph.D. or M.D. and expertise in techniques of cell and molecular biology. Familiarity with experimental techniques required for the study of small blood vessels is preferred but not required. University of Maryland is an Equal Opportunity Employer encouraging excellence through diversity. Qualified woman and minority candidates are encouraged to apply.
Responsibilities
The federally funded project examines vascular smooth muscle gene expression and contractility in the regulation of blood flow in development and disease models, focusing on myosin phosphatase editing in animal models.