Post Doctoral.Post Doctoral.Associate at UPMC

Pittsburgh, Pennsylvania, United States -

Full Time

Start Date

Immediate

Expiry Date

23 Jun, 26

Salary

0.0

Posted On

25 Mar, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Molecular Biology, Cellular Biology, Gene Analysis, Protein Analysis, QPCR, Western Blot, Cloning, Alternative Splicing, RNA-Binding Proteins, Experimental Design, Data Analysis, Statistical Analysis, Scientific Writing, Metabolism Knowledge, Retinal Biology, Neuroscience

Industry

Hospitals and Health Care

Description

The University of Pittsburgh, Ophthalmology Department is searching for a Post Doctoral Associate. This project will clarify the isoform-specific roles of BSG in retinal physiology and establish their importance in metabolic homeostasis. Ultimately, it may uncover novel therapeutic strategies for diseases such as retinitis pigmentosa, retinopathic diabetic, or age-related macular degeneration. Along with the research added repressibilities would be to help train Students and new lab members, Participate in publications from the lab, verify lab supplies are kept in stock and participate in procedure creation. Essential Skills (must have at entry) 1. Molecular and Cellular Biology · Solid experience in gene and protein analysis (qPCR, Western blot, cloning) · Understanding of alternative splicing mechanisms · Familiarity with RNA-binding proteins (e.g., HNRNPs is a plus) 2. Experimental Design & Data Analysis · Ability to design rigorous experiments and interpret complex datasets · Experience with statistical analysis and reproducibility standards · Scientific writing skills (papers, grant contributions) 3. Basic Metabolism Knowledge · Understanding of cellular metabolism (glycolysis, mitochondrial function, redox balance) · Familiarity with metabolic stress pathways Strongly Preferred Skills 1. Retinal Biology / Neuroscience · Knowledge of photoreceptor biology and retinal organization · Experience with retinal models (mouse or in vitro systems) 2. Mouse Genetics and In Vivo Work · Experience with transgenic or knockout mouse models · Phenotyping (histology, immunohistochemistry, functional assays such as ERG is a plus) 3. Protein Interactions and Signaling · Experience studying signaling pathways (e.g., ligand–receptor interactions like RdCVF–BSG) · Techniques such as co-immunoprecipitation or proximity assays PhD in Molecular or Cellular Biology or like degree required

Responsibilities

The primary research responsibility involves clarifying the isoform-specific roles of BSG in retinal physiology and establishing their importance in metabolic homeostasis to potentially uncover novel therapeutic strategies. Additional duties include assisting in training students and new lab members, contributing to lab publications, managing lab supply inventory, and participating in procedure creation.