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Post Doctoral.Post Doctoral.Associate at UPMC
Pittsburgh, Pennsylvania, United States -
Full Time

Start Date

Immediate

Expiry Date

31 Aug, 26

Salary

0.0

Posted On

02 Jun, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

No

Skills

Cell Biology, Molecular Biology, Metabolomics, Proteomics, RNA Sequencing, Neurobiology, Problem Solving, Independent Research

Industry

Hospitals and Health Care

Description
The Thomas Lab in the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine is seeking a highly motivated Postdoctoral Associate to join our team. Our research investigates how recurrent mutations in PACS1 and PACS2 drive severe neurodevelopmental disorders. We focus on the impact of these mutations on microtubule-based transport, membrane contact sites, and calcium homeostasis in vivo. A central goal of the lab is to understand how de novo variants in these genes disrupt proteostasis, neuronal metabolism, and neurotransmission. The successful Candidate will employ a combination of cell and molecular biology approaches alongside systems-level techniques, including metabolomics, proteomics, and RNA sequencing, to dissect disease mechanisms. This position offers the opportunity to contribute to ongoing NIH-funded projects in a collaborative and interdisciplinary research environment. Qualifications PhD in cell biology, neurobiology, or a related discipline Strong background in laboratory-based research Demonstrated experience with cell and molecular biology techniques Familiarity with omics approaches (metabolomics, proteomics, RNA-seq) is highly desirable Ability to work independently and as part of a team, with strong problem-solving skills Qualified candidates, please apply to requisition # 26002360 at this link: Home | Talent Center: Careers at Pitt | University of Pittsburgh
Responsibilities
The candidate will investigate how PACS1 and PACS2 mutations drive neurodevelopmental disorders by studying microtubule-based transport and calcium homeostasis. They will utilize cell biology and systems-level techniques like proteomics and RNA sequencing to dissect disease mechanisms.