THE OPPORTUNITY:

We are seeking applications for a PDRA to join the dynamic research group of Dr Denby working on an exciting translational MRC funded study in which we are targeting scar-associated monocyte-derived macrophages (SAMac) to reduce fibrosis and the mechanisms associated with this. This project is in collaboration with the Ramachandran and Walmsley research labs of the Institute of Regeneration and Repair (IRR). This cutting-edge project involves sc/sn RNA sequencing and analysis of human and mouse kidney and liver samples, spatial transcriptomics, multiplex tissue staining, informative transgenic animal studies and metabolomics. The Denby lab is located in the Institute of Neuroscience and Cardiovascular Research (INCR) and is part of Edinburgh Kidney ( https://edinburghkidney.co.uk/ ). The studies to be undertaken will be conducted between INCR and the IRR.

YOUR SKILLS AND ATTRIBUTES FOR SUCCESS:

• The candidate must have a PhD (submitted or obtained) in immunology / biological sciences or related.
• Strong theoretical knowledge of the mechanisms driving fibrosis.
• Theoretical knowledge / experience of the application of flow cytometry and cell sorting.
• Experience in metabolomics and/or immunometabolism
• Experience in bioinformatic analysis of sc/sn RNA sequencing data
• Practical knowledge of cell culture and immunostaining.Knowledge of pre-clinical models of fibrosis.
• 
  Click to view a copy of the full job description (opens new browser tab).
  Informal enquiries are welcomed and can be addressed to Dr Laura Denby, Laura.Denby@ed.ac.uk

Please refer the Job description for details