Start Date
Immediate
Expiry Date
07 May, 25
Salary
0.0
Posted On
07 Feb, 25
Experience
0 year(s) or above
Remote Job
No
Telecommute
No
Sponsor Visa
No
Skills
Working Environment, Life Sciences, Remuneration, Personal Development, International Networking, Data Analysis
Industry
Information Technology/IT
„Research for a life without cancer“ is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts - whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.
The Division of Molecular Genetics is seeking from April 2025 a
SCIENTIST / POSTDOC IN THE FIELD OF CANCER PLASTICITY
Reference number: 2025-0032Your Tasks
We are looking for a scientist / postdoc to work on the regulation of phenotypic plasticity and therapy resistance by redox and metabolic signaling in brain tumors.
The project is part of a research consortium receiving long-term funding by the Carl Zeiss Stiftung. The overall goal of the consortium is to use advanced molecular profiling of glioblastoma organoid models and artificial intelligence methods to map mechanisms of therapy resistance and vulnerabilities.
In this context, we will focus on the redox- and epigenetic mechanisms governing glioblastoma cell-state transitions and tumor phenotype, building on our previous work on the metabolic enzyme BCAT1 and its effects on cell division, DNA methylation and cellular differentiation. We will use engineered iPSC-derived tumor-organoids as well-defined and brain tumors models. Organoid gene expression and phenotypes will be analyzed by scRNA-Seq and epigenetic profiling after pharmacologic and genetic manipulation. In collaboration with our consortium partners, we will use AI to map tumor plasticity landscapes and identify and experimentally validate approaches inducing and exploiting tumor-specific therapy vulnerabilities.
More information can be found at https://www.dkfz.de/en/molecular-genetics/phenotypic-plasticity.
Your Profile
Applicants should hold a M.Sc. and PhD degree in biology / life sciences with a neuroscience/tumor biology background and have an excellent command of the English language. German language skills are of advantage, but not required. Experiences in iPSC or organoid model systems and sequencing data analysis are desirable.We Offer
Please refer the Job description for details