Postdoc in epistasis-aware AI models for protein engineering - BRIGHT at Danmarks Tekniske Universitet

Copenhagen, Capital, Denmark -

Full Time

Start Date

Immediate

Expiry Date

27 Aug, 26

Salary

0.0

Posted On

29 May, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Protein Engineering, AI Modeling, Biocatalysis, Kinetic Modelling, Next Generation Sequencing, Protein Expression, Protein Purification, Biochemical Assays, Biophysical Assays, Chemical Engineering, Applied Chemistry, Enzyme Engineering, Data Analysis, Scientific Writing, Teaching, Supervision

Industry

Research Services

Description

The Computational Protein Engineering (CPE) group at The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition (BRIGHT) is developing novel methods to engineer proteins more effectively using state-of-the-art experimental and computational approaches. Our mission is to develop innovative and sustainable solutions to the most pressing issues facing our societies in terms of bioproduction and bioremediation. To support this goal, we are looking for a colleague who is independent, who thrives within an interdisciplinary environment at a world-class research centre, and who is highly motivated to move the area of enzyme engineering to the next level, while having a positive impact on our world. When joining our team, you get the opportunity to use the latest algorithms in machine learning for improving enzyme activity, selectivity, and/or stability, etc. We currently work with enzymes involved in the biosynthesis of natural products and biochemicals as well as in the breakdown of greenhouse gases including CO2 and CH4. Responsibilities and qualifications Responsibilities: * Develop novel workflows for the high-throughput generation of data on enzyme kinetics * Engineer multiple enzyme properties using experimental and computational methods * Variant identification using next generation sequencing (e.g., Nanopore) * Protein expression, purification and characterization using biochemical and biophysical assays * Develop epistasis-aware AI models for protein engineering with computational experts * Report your results in peer-review scientific publications and international conferences * Teach and supervise PhD, MSc and BSc students as well as research assistants Qualifications: * PhD in chemical engineering and applied chemistry * Experience with biocatalysis, protein engineering and chemical engineering * Experience with kinetic modelling, protein and process engineering of dehydrogenases * Strong publication record of peer-review original scientific articles * Excellent English proficiency in written and oral form * Excellent communication and social skills for working within an interdisciplinary research team * Strong analytical skills and ability to work independently As a formal qualification, you must hold a PhD degree (or equivalent). We offer DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. Salary and terms of employment The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 1.5 years. The preferred starting date is 1st June 2027 (or according to mutual agreement). The position is full time. You can read more about career paths at DTU here [http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths]. Further information Further information may be obtained from Carlos Acevedo-Rocha: cargac@biosustain.dtu.dk [cargac@biosustain.dtu.dk] Google Scholar profile: https://scholar.google.com/citations?hl=en&user=yZDS88IAAAAJ [https://scholar.google.com/citations?hl=en&user=yZDS88IAAAAJ] More information about BRIGHT: https://bright.dtu.dk/ [https://bright.dtu.dk/] CPE group: https://www.biosustain.dtu.dk/research/research-areas/natural-products/computational-protein-engineering [https://www.biosustain.dtu.dk/research/research-areas/natural-products/computational-protein-engineering] If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark [https://www.dtu.dk/english/about/job-and-career/moving-to-denmark]. Application procedure Your complete online application must be submitted no later than 14 June 2026 (23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include: * Application (cover letter) * CV * Academic Diplomas (MSc/PhD – in English) * List of publications Applications received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position. About BRIGHT – The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition (BRIGHT) is a major initiative based at DTU that aims to accelerate the development of biosolutions and strengthen the bio-based economy. BRIGHT serves as a hub for academic and industrial partners working together to unlock the potential of bioproduction. BRIGHT focuses on three main areas: Sustainable materials (Developing bio-based alternatives to fossil-derived materials), Microbial foods (Innovating food production through microbial technologies), and Microorganisms for net-zero agriculture (Creating solutions to reduce greenhouse gas emissions in agriculture). The goal is to develop and scale innovative biosolutions within these areas, ultimately creating sustainable and competitive alternatives to fossil-based products and processes that can make significant contributions to reducing global greenhouse gas emissions. DTU – For the benefit of society since 1829 DTU is one of Europe's leading elite technical universities. Through research and education at an international top level, we create solutions to the major societal challenges of our time and help secure Europe's global leadership in sustainable technological development. Since Hans Christian Ørsted founded DTU almost 200 years ago, our mission has remained the same: We develop and create value through the natural and technical sciences for the benefit of society. DTU has 13,800 students, 1,600 PhD students, and 6,500 employees. We work in an international environment and have an inclusive, stimulating, and informal work culture. DTU has campuses in all parts of Denmark and in Greenland and collaborates with the best universities around the world.

Responsibilities

Develop epistasis-aware AI models and novel workflows for high-throughput enzyme kinetics data generation. Engineer enzyme properties using experimental and computational methods while supervising students and publishing results.