Aparicio Lab
Application Deadline
Sep 30, 2025
The expected salary range for this position is $60,000-$80,000 per annum.
At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.
The Aparicio Laboratory in the Department of Pathology and Laboratory Medicine is seeking a full-time (1.0 FTE) Postdoctoral Research Fellow to join the Aparicio Lab at the BC Cancer Research Institute to work on drug target discovery and therapeutics in genomically unstable adult and pediatric cancers. The project is tackling an unmet need by identifying modality combinations of antibodies/ADCs and small molecules. We are addressing combinatorial target identification with CRISPR functional genomics and chemical biology for targeting hard to treat cancers. The Aparicio Lab has a long track record of high impact discoveries in cancer genomics and translation to human studies (aparicio.molonc.ca), including biotech company creation. Our environment is a fast paced multidisciplinary lab, offering training and experience in genomics, computational biology, early drug discovery and clinical studies.

QUALIFICATIONS

Successful applicants will have:

• A PhD with experience in chemical biology in the domain of cancer biology
• Proficiency in statistical/computational analysis of chemical and functional screen data to be self-sufficient in interpretation
• Experience with tumor model systems, including isogenic knockouts, organoids and/or PDX systems
• Experience in the design and use of CRISPR functional genetics screening approaches and chemical library screening approaches will be an advantage
• Excellent organizational skills and attention to detail.
• Effective communication and teamwork abilities.
• Ability to work independently with minimal supervision and prioritize tasks effectively.
• Commitment to upholding quality standards, safety protocols, and regulatory compliance.
• Willingness to respect diverse perspectives, including perspectives in conflict with one’s own.
• Demonstrates a commitment to enhancing one’s own awareness, knowledge, and skills related to equity, diversity, and inclusion.

The expected salary for this position is $60,000-$80,000 per annum. The Faculty of Medicine is committed to offering equitable and competitive salaries, commensurate with the qualifications and experience of the candidate.

Reporting to Dr. Sam Aparicio, the incumbent will be responsible for:

• Design of chemical biology approaches for exploration of combinatorial targeting and therapeutic proof of concept
• Establishment of relevant isogenic cell line backgrounds for screens
• Engaging with other team members on combinatorial CRISPR screen strategies for target credentialing in cancer models
• Computational analysis of screen data
• Design and execution of combinatorial target validation experiments in PDXO and PDX systems in the lab
• Record and analyze experimental data accurately and efficiently, maintaining detailed records and documentation.
• Training and supervision of graduate students and/or research assistants.
• Adhere to safety protocols and guidelines at all times, including proper handling and disposal of hazardous materials.