POSTDOCTORAL ASSOCIATE - BRENNER LAB at Sanford Burnham Prebys Medical Discovery Institute

San Diego, California, United States -

Full Time

Start Date

Immediate

Expiry Date

29 Sep, 26

Salary

77334.4

Posted On

01 Jul, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Mammalian Cell Culture, Molecular Biology, Lentiviral Production, Gene Overexpression, Gene Knock-down, Gene Knock-out, Mouse Handling, In Vivo Techniques, Tissue Processing, Primary Cell Isolation, Immunohistochemistry, Microscopy, Bioinformatics, RNAseq Analysis, Research Design, Grant Writing

Industry

Biotechnology Research

Description

Sanford Burnham Prebys is much more than a research facility and hub for innovation; it’s a vibrant global community of talented scientists and researchers from over 30 countries. This worldwide representation enriches our perspectives and enhances our creative approach to solving complex scientific challenges. We strive to be leaders not only in biomedical research but also in creating an environment where excellence thrives through collaboration across cultures and backgrounds. Our mission is to advance the biomedical sciences by cultivating the next generation of scientific leaders, providing meaningful opportunities for researchers of all backgrounds to learn, innovate, and make breakthrough discoveries that improve human health. Together, we translate science into health. The duties and responsibilities contained in the job description are intended to be examples of the accountabilities for which the person in the position will demonstrate competency through performance. The job description is not intended to be an all-inclusive list. Duties and responsibilities are subject to change and other duties may be assigned as necessary. Position Summary: Research in the Brenner lab (https://sbpdiscovery.org/scientists/david-a-brenner-md/ [https://sbpdiscovery.org/scientists/david-a-brenner-md/]) studies a wide variety of liver diseases, such as liver fibrosis, HCC and Metabolic dysfunction associated steatohepatitis (MASH) and Alcohol associated liver disease (ALD). Using both in vivo mouse models as well as primary human cells, the overarching goal of the lab is to understand the cell-cell interaction and the basic mechanisms of disease development in order to identify novel therapeutic approaches. A Postdoctoral Associate position is available to study: * The mechanism of liver fibrosis and liver cancer development. * Understand the mechanism of activation of hepatic stellate cells in MASH. Under limited direction, the Postdoctoral Associate will plan and manage all aspects of a research project including research design, experimentation, funding acquisition and publication. Duties and Responsibilities: * Research design and planning * Experimentation and trouble-shooting * Data collection, analysis and interpretation * Data recording and compliance * Management of collaborations * Results summarization * Preparation of grants and manuscripts Education and/or Experience: * Ph.D. in biomedical sciences * Experience with mammalian cell culture, molecular biology techniques, lentiviral production, overexpression and knock-down or knock-out genes in vitro * Expertise in mouse handling and in vivo techniques such as i.v., IP, oral gavage, sub-cutaneous injection is required * Experience in harvesting and processing various mouse tissues in required. * Isolation of various primary cell types from the liver in preferable * Experience with immunohistochemistry and microscopy is required * Ability to perform basic bioinformatics analysis of bulk or single cell RNAseq data is preferable. Other Knowledge, Skills and/or Abilities: * Demonstrated ability to conduct and publish research projects * Work independently as well as in a team environment * Be responsible and have strong time management skills * Able to analyze and resolve issues of high/moderate complexity * Possess strong attention to detail and organizational skills * Demonstrate professional communication and interpersonal skills * Professional proficiency in Microsoft Office, Adobe Photoshop/Illustrator, Prism, ImageJ * Embody the Institute’s core values of Commitment, Collaboration, Communication, Community and Compassion Supervisory Responsibilities: This position has no supervisory responsibilities. Work Location: This is an onsite position; candidates must be willing to work onsite in San Diego. Out-of-state applicants must disclose their willingness to relocate. Compensation: The expected salary for this position is $70,304.00 - $77,334.40 annually, commensurate with postdoctoral experience. We welcome talented individuals of all backgrounds regardless of gender, sex, religion, race, national origin, citizenship, age, disability, perceived disability, pregnancy, pregnancy-related condition, reproductive health decisions, sexual orientation, gender identity, gender expression, genetic information, HIV/AIDS, marital status, covered veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. We are proud to be an equal employment opportunity employer. As part of this commitment, Sanford Burnham Prebys Medical Discovery Institute will ensure that persons with disabilities are provided reasonable accommodations for the hiring process. If a reasonable accommodation is needed, please contact our Benefits Team at (858) 646-3100 or via e-mail at benefits@sbpdiscovery.org [benefits@sbpdiscovery.org]

Responsibilities

The Postdoctoral Associate will plan and manage research projects focused on liver fibrosis, liver cancer, and MASH. Responsibilities include experimentation, data analysis, managing collaborations, and preparing grants and manuscripts.