Sanford Burnham Prebys is much more than a research facility and hub for innovation; it’s a vibrant global community of talented scientists and researchers from over 30 countries. This worldwide representation enriches our perspectives and enhances our creative approach to solving complex scientific challenges.
We strive to be leaders not only in biomedical research but also in creating an environment where excellence thrives through collaboration across cultures and backgrounds. Our mission is to advance the biomedical sciences by cultivating the next generation of scientific leaders, providing meaningful opportunities for researchers of all backgrounds to learn, innovate, and make breakthrough discoveries that improve human health.
Together, we translate science into health.
The duties and responsibilities contained in the job description are intended to be examples of the accountabilities for which the person in the position will demonstrate competency through performance. The job description is not intended to be an all-inclusive list. Duties and responsibilities are subject to change and other duties may be assigned as necessary.
The Karin Lab is Seeking a Postdoctoral Associate.

REQUIRED SKILLS:

• Designing and performing complex, scientific experiments relevant to applicable research goals
• initiating, developing, implementing, and ensuring compliance with all required protocols; ensuring adherence to EH&S regulations.
• Overseeing mouse colony maintenance
• Training and overseeing students and technicians in the lab in running scientific experiments to support laboratory research studies
• Analyzing and interpreting scientific data
• Collaborating with other researchers
• Reviewing relevant studies and research articles in the professional, scientific literature in directly related and applicable fields
• Writing for research grant proposals; and preparing research results for dissemination by authoring articles for submission and publication in professional, scientific peer-reviewed journals
• Presenting at professional, scientific and scholarly conferences and meetings.

REQUIRED EDUCATION AND EXPERIENCE:

• Education: Ph.D. or other advanced degree in a biological science or related field
• Experience: Three (3) years or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained is required
• Certifications, Licenses, etc: None

ADDITIONAL SKILLS AND EXPERIENCE:

• Demonstrated ability to conduct and publish research projects
• Work independently as well as in a team environment
• Be responsible and have strong time management skills
• Able to analyze and resolve issues of moderate complexity
• Possess strong attention to detail and organizational skills
• Demonstrate professional communication and interpersonal skills
• Professional proficiency in Microsoft Office

Under general direction and independently and/or as part of a team, apply scientific and cross- functional knowledge to achieve project goals by designing, executing, interpreting complex experiments and generating comprehensive reports, the Postdoctoral Associate will:

• Assist with and Conduct scientific research on inflammation and metabolism in MASLD and hepatocellular carcinoma progression under Dr. Michael Karin Ph.D., incoming Professor at the Institute.
• Develop novel anti-MASLD/MASH and cancer therapies based on specific target molecules and the molecular mechanisms underlying disease initiation/progression related to inflammation and metabolism. Specifically, will elucidate the role of macrophages in the progression of MASLD/MASH and HCC.
• Perform a wide variety of experimental research techniques related to liver disease biology research.
• Independently perform RNA sequencing and cell signaling analyses, cell-sorting, immunofluorescence staining, IHC Scoring and independently collect and analyze the resulting data.
• Work with genetically engineered mouse models of development of nonalcoholic steatohepatitis and hepatocellular carcinoma, and human cell lines of pancreatic cancer and hepatocellular carcinoma for investigating novel immunotherapeutic and molecular targeted drugs. In addition, knowledge of cell isolation from specific tissues with magnetic beads and FACS, followed by functional analysis of these cells in the development and progression of nonalcoholic steatohepatitis and hepatocellular carcinoma, is of importance. The goal of his research is to develop a novel cancer therapeutic strategy for better patient outcomes

DUTIES AND RESPONSIBILITIES:

Under general direction and independently and/or as part of a team, apply scientific and cross- functional knowledge to achieve project goals by designing, executing, interpreting complex experiments and generating comprehensive reports, the Postdoctoral Associate will:

• Assist with and Conduct scientific research on inflammation and metabolism in MASLD and hepatocellular carcinoma progression under Dr. Michael Karin Ph.D., incoming Professor at the Institute.
• Develop novel anti-MASLD/MASH and cancer therapies based on specific target molecules and the molecular mechanisms underlying disease initiation/progression related to inflammation and metabolism. Specifically, will elucidate the role of macrophages in the progression of MASLD/MASH and HCC.
• Perform a wide variety of experimental research techniques related to liver disease biology research.
• Independently perform RNA sequencing and cell signaling analyses, cell-sorting, immunofluorescence staining, IHC Scoring and independently collect and analyze the resulting data.
• Work with genetically engineered mouse models of development of nonalcoholic steatohepatitis and hepatocellular carcinoma, and human cell lines of pancreatic cancer and hepatocellular carcinoma for investigating novel immunotherapeutic and molecular targeted drugs. In addition, knowledge of cell isolation from specific tissues with magnetic beads and FACS, followed by functional analysis of these cells in the development and progression of nonalcoholic steatohepatitis and hepatocellular carcinoma, is of importance. The goal of his research is to develop a novel cancer therapeutic strategy for better patient outcomes.