The goal of the project is to identify engineered proteins that can be useful as antimicrobials or as therapies that combat host responses to microbial infections. The approach uses a rational choice of a starting scaffold, informed by manufacturing considerations and a desire to enable non-invasive means of administration. Methods for efficient screening of combinatorial libraries of protein variants will be used, and there is also the oportunity to incorporate machine learning approaches to connect sequence with activity, with the eventual goal of enabling reliable predictive power.
Central responsibilities are protein engineering (generation of candidates to evaluate for in vivo efficacy) and generation of data that answers questions about activity (ability of engineered proteins to prevent invasion of host cells or prevent dysregulated immune response), immunogenicity, and pharmacokinetics/pharmacodynamics.
The successful candidate will be skilled in planning and conducting experiments, and will enjoy working with others as part of a team. The AMR IRG has an unusual model where several PIs work closely together, sharing lab space, equipment, and a core team of laboratory technicians that support all projects.

Relevant laboratory skills and experience include:

• applied molecular biology for biomolecular engineering
• protein engineering using yeast surface display
• microbial cell culture (bacteria and yeast)
• next-generation sequencing
• high throughput screening
• flow cytometry

REQUIREMENTS

• PhD in Chemical/Biomolecular/Biological Engineering or related field
• Commitment to reading and synthesizing peer-reviewed and patent literature
• Commitment to publishing peer-reviewed journal articles
• Ability to work well with others
• Careful record keeping
• Strong communication skills (scientific writing and oral presentation)
• Skill in experimental design (systematic studies, informative controls)
  Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.

Please refer the Job description for details