Postdoctoral Fellow - Investigating a novel metabolic fuel switch regulator

at  AstraZeneca

ESSENTIAL REQUIREMENTS

• A PhD in Biology, Biochemistry, Physiology, Biomedical Sciences or a related field
• Strong Cell and Molecular Biology skills
• Excellent working experience in conducting in vivo studies and isolating cells from different organs
• Expertise in metabolic in vitro experiments
• Proven track-record in leading scientific projects, resulting in publications
• Passionate about science - Your ability to conduct independent and innovative research is vital
• Outstanding written and verbal communication skills
• Exceptional collaborator - Working effectively in a team, exchanging ideas, and contributing to joint research efforts.

Our Postdoc programme is aimed at individuals who are either:

• Within 5-years of obtaining their doctoral degree (PhD, DVM, or MD) - PhD already awarded, or
• Students, soon to obtain doctoral degrees (the PhD must be awarded within 6 months of joining AstraZeneca)

DESIRABLE REQUIREMENTS

• Understanding of transcriptomic, proteomic and metabolomic data analysis.
• Experience and knowledge of the principles of metabolic regulation
• Appreciation of physiology and interorgan communications
• Understand mechanisms of protein post-translational modifications

Our Postdoctoral Fellow will lead an independent project in a supportive and team-oriented environment with the aim to investigate the mechanistic role of a newly discovered metabolic fuel switch regulator at the molecular level. This regulator has shown to have a major impact on metabolic fuel usage in the liver by increasing lipid oxidation and reducing glycolysis. Furthermore, you will explore not only the mechanism underlying the fuel switch governed by this regulator, but also the implications of the hepatic changes on cardiac function.