Postdoctoral Fellow – Molecular Neurogenetics at Lieber Institute Inc

Baltimore, Maryland, United States -

Full Time

Start Date

Immediate

Expiry Date

21 May, 26

Salary

75564.0

Posted On

20 Feb, 26

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Molecular Cell Biology, Stem Cell Culture, iPSC Culture, Trophoblast Differentiation, Neuronal Differentiation, Immunocytochemistry, Single-Molecule FISH, ELISA, Western Blot, RT-qPCR, Proteomics Sample Preparation, Metabolomics Sample Preparation, Single-Cell Transcriptomics, Spatially-Resolved Transcriptomics, Experimental Design, Data Analysis

Industry

Research Services

Description

Description A little about us: The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the “holy grail” in medical research, the discovery of strategies for primary prevention. We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD. Job Summary: We are seeking an enthusiastic and self-motivated postdoctoral associate with experience in molecular cell biology to join our interdisciplinary research team at the Lieber Institute for Brain Development, located on the Johns Hopkins medical campus in Baltimore, Maryland (https://www.libd.org/functional-genomics/). This position is open to scientists seeking a position within a translational research setting with a focus on human stem cell projects using induced pluripotent stem cell (iPSC)-derived trophoblasts and neuronal cells. The successful applicant will work closely in collaboration with a team of wet bench and computational scientists to investigate the consequences of compromised pregnancy on neurodevelopment with the goal of deciphering in utero mechanisms underlying neurodevelopmental and psychiatric disorders. Responsibilities will include experimental design, executing protocols independently, analyzing data, as well as communicating scientific findings through presentations and publications. Overview of Duties: -Culturing human iPSC and derivative cell lines -Immunocytochemistry, single-molecule FISH, ELISA, western blot, RT-qPCR -Sample preparation for proteomics, metabolomics, single-cell transcriptomics, and spatially-resolved transcriptomic analyses -Maintain detailed experimental records and ensure reproducibility of protocols -Other duties as assigned Requirements Required Minimum Qualifications: -PhD in cell and molecular biology, neuroscience, or a closely related field -Cellular and molecular biology and/or neuroscience experience -Bench experience with culturing stem cells, molecular profiling assays or transcriptomic analysis would be beneficial Required Special Knowledge, Skills and Abilities: -Flexible work schedule (this position will require work for extended hours and on weekends and holidays, depending on the cell culture schedule) -Exceptional wet lab skills -Computational experience or familiarity with computing in R or Python is a plus. -Strong motivation to learn new methods and perform work efficiently and carefully are essential. -Strong troubleshooting skills and ability to independently resolve technical challenges -Excellent communication and collaborative skills, with ability to work effectively in a team-based environment Familiarity with any of the following topics or techniques is a plus: -Human PSC culture and trophoblast and/or neuronal differentiation -Programming in R or Python -Proteomics or metabolomics analysis -Single-cell or spatially-resolved transcriptomic analysis -Experience leading manuscript preparation -Human placental biology -Human neurodevelopmental biology Physical Requirements: · Remaining in a seated or standing position for extended periods of time; · Reaching and grasping to manipulate objects with fingers; · Mobility, including the ability to maneuver around a laboratory setting including the ability to move materials weighing up to 25 pounds; · Communication skills using the spoken and written word; · Having the ability to receive detailed information through oral communication; · All other physical demands in a standard laboratory environment. ** If accommodations are needed due to pregnancy or a disability, please contact jobs@libd.org. Compensation Compensation will be based on the candidate’s postdoctoral experience and is consistent with the NIH NRSA stipends, which currently range from $62,232 (entry-level) to $75,564 (7+ years of experience). Benefits The Lieber Institute for Brain Development offers a competitive, comprehensive benefits package to help us attract and retain the best talent. Please visit https://www.libd.org/careers/benefits/ for more information. EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified. LIEBER INSTITUTE FOR BRAIN DEVELOPMENT'S COMMITMENT TO DIVERSITY, EQUITY, AND INCLUSION The Lieber Institute for Brain Development is a transparent and collaborative community working to produce unique and imaginative patient-oriented solutions to developmental neuropsychiatric disorders. It is committed to integrating scientists from diverse disciplines, cultures, and countries into a research team that draws upon the best of its staff. The Institute is historic—it is defining a unique model for ground-breaking science. It values translational science that revolutionizes the field and improves the quality of life for those affected by mental illness. The Institute provides an environment that fosters independent growth through mentorship and a supportive, collegial community. Diverse minds, ideas, and talent are needed to support LIBD's mission. Fresh, innovative ideas and perspectives are a competitive necessity in an increasingly diverse and global marketplace. The success of the Institute's mission depends upon leveraging a diversity of talent. The Institute's commitment to diversity goes beyond compliance with laws and regulations that promote equal employment opportunity, prohibit discrimination and harassment, and support minority and woman owned businesses. To realize the advantages of its diversity, it is necessary to work effectively together even when differences challenge us to consider ideas and methods that seem impractical or make us feel uncomfortable. The Lieber Institute for Brain Development demonstrates its commitment to diversity by: · Including others: Talent is not limited to those with a narrow set of industry and academic credentials. The Institute is committed to building diverse teams, inviting others to share their perspectives, seeking out a diversity of input when making decisions, questioning traditional thinking, and promoting continuous learning and development. · Respecting one another: The Institute is committed to listening carefully to others, seeking consensus, engaging in active and constructive debate, thoughtfully challenging one another, and providing constructive feedback. · Building trust: The Institute is committed to sharing information and resources, depending on one another to get things done, keeping promises, and conveying high integrity in all actions.

Responsibilities

Responsibilities include experimental design, independently executing protocols, analyzing data, and communicating scientific findings through presentations and publications within a translational research setting focused on human stem cell projects.