Description
The Horowitz Laboratory is seeking a highly motivated postdoc to lead projects focused on basic and translational immunology. This opportunity is designed to study crosstalk between immune cells, stroma and tumors within tumor microenvironments in patients with cancer or autoimmunity. The candidate will actively participate in research studies that focus on evaluating the immune response in cohorts of patients treated with immunotherapy. Specifically, the candidate will be expected to manipulate solid tissues suitable for preparation to perform an array of experimental modalities, including but not limited to mass cytometry (CyTOF), single-cell RNA sequencing, spatial sequencing, multiplexed imaging, as well as in vitro and/or in vivo functional assays to assess immune responses in PBMCs/TILs from cancer patients. Additionally, the candidate will develop sequencing-based methodologies for sequencing HLA class I and class II and KIR genes. The responsibilities in this research include developing new immune assay approaches, improve the collection of clinical samples from cancer or precancerous patients through collaboration with clinicians (i.e. Urologic Oncologists), assist in interpreting moderately complex results, assist in the collection, analysis and review of experimental data for publication and presentation, and participate in laboratory meetings to present the progress of your research. She/He/They is expected to assist in scientific writing, developing novel research techniques and mentoring of Associate Researchers and Graduate trainees. A strong knowledge of NK cell, T cell, and myeloid cell immunology, Tumor immunology and experience with experimental methods to measure immune responses (T cell proliferation, ELISPOT, Tetramers, killing assays) is desirable. Applicants are required to have strong backgrounds in computational immunology and expertise in programming languages (e.g., R, Python). Most importantly, applicants are expected to maintain exceptional communication with the principal investigator. They are expected to present weekly progress at lab meetings as well.
Responsibilities

Essential Job Functions (including but not limited to):

• Conduct and design experiments under the direction of the lab PI. Conduct a variety of research experiments using advanced research techniques specific to subject matter of the research project (i.e. performing basic molecular and cellular biology methods including tissue culture as well as biochemistry techniques such as cytotoxicity assays, PCR, Western Blot and analysis of samples through flow cytometry, CyTOF, scRNA sequencing, etc). Must be able to read and understand scientific data being applied to conduct the research.
• Coordinates project activities to meet deadlines.
• Collaborates with the Principal Investigators in the development of new experiments and research techniques. Incumbents are expected to stay apprised of the literature as well as practical skill sets relevant to the field.
• Assists in the implementation of standardized protocols for experiments and training purposes; create and maintain Standard Operating Procedures (SOPs) specific for each study.
• Assists the Principal Investigator with publications by extracting and compiling moderate to complex research data (i.e. related to oncology, immunology, microbiology, etc); assisting in interpreting the data; reviewing and editing articles used in scientific publication. Must have strong science background.
• Mentors and trains less experienced research staff and graduate students in research techniques and use of equipment.
• Ensures compliance with safety and regulatory requirements.
• Performs other related duties.

Qualifications

Qualifications:

• Ph.D. required
• Experience working in a research laboratory setting
• The candidate is also expected to be highly self-motivated, creative and capable of contributing productively in a team environment.

This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW.
Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf.
Employer Description

Please refer the Job description for details