Job Type: Regular
Time Type: Full time
Work Shift: Day (United States of America)
FLSA Status: Exempt

WHEN YOU JOIN THE GROWING BILH TEAM, YOU’RE NOT JUST TAKING A JOB, YOU’RE MAKING A DIFFERENCE IN PEOPLE’S LIVES.

Job Title: Postdoctoral Research Fellow position available in X-ray Crystallography and Cryo-EM of Proteins Regulating Triglyceride Metabolism.
About Us: Join our dynamic research team dedicated to unraveling the mysteries of triglyceride metabolism. We are seeking a talented and motivated Postdoctoral Scientist to lead cryo-electron microscopy (cryo-EM) and X-ray crystallography studies on proteins involved in the regulation of triglyceride metabolism. This position provides a unique opportunity to contribute to cutting-edge research with direct implications for metabolic health. The Birrane Lab is located at the Beth Israel Deaconess Medical Center and Harvard Medical School in the Longwood area of Boston, Massachusetts. We have regular access to synchrotron beamlines (NSLS-II, APS) and state-of-the-art cryo-EM facilities at Harvard Medical School and MIT.
Position Overview: As a Postdoctoral Fellow, you will be at the forefront of our efforts to understand the structural basis of proteins influencing triglyceride metabolism. Utilizing your expertise in Protein expression and purification, X-ray crystallography and/or cryo-EM, you will play a crucial role in unraveling the molecular mechanisms that underlie the regulation of triglyceride homeostasis. This position offers a stimulating and collaborative environment for scientific exploration.

Key Responsibilities:

• Conduct X-ray crystallography experiments to determine high-resolution structures of proteins involved in triglyceride metabolism.
• Apply cryo-EM techniques for structural analysis of protein complexes and interactions.
• Work collaboratively with the research team to design and execute experiments.
• Analyze and interpret experimental data, contributing to the preparation of scientific publications.
• Stay abreast of the latest developments in structural biology and lipid metabolism.

Preferences:

• Ph.D. in Structural Biology, Biochemistry, or a related field.
• Proven expertise in X-ray crystallography and/or cryo-EM techniques.
• Excellent analytical and problem-solving skills.
• Effective communication skills and the ability to work collaboratively in a team.
• Experience in protein expression, purification, and biochemical characterization.
• Familiarity with software tools for data processing and structure determination.
• Strong background in proteins related to lipid metabolism or cellular signaling.
• Track record of successful contributions to peer-reviewed publications.

PRIMARY RESPONSIBILITIES:

• Abides by the institutional policies of BIDMC relating to health and safety, equality of opportunity and data storage and management. (essential)
• As a member of the research team, actively pursues research under the supervision of a principal investigator while developing skills for independent work. (essential)
• Receives training in and performs duties contributing to the investigational work of the team including formulation of research questions and design, conduct of experiments, and evaluation of results. (essential)
• Prepares and publishes scientific manuscripts under direction of PI. (essential)
• Develops expertise in desired lab skills/informatics/ physics/clinical research. Develops proficiency with research tools and equipment. Develops ability to work with more independence as the fellowship progresses (essential)
• Develops new ideas that promote current research; brings new expertise to the research program. (essential)
• teaching skills and provide supervision of students and their projects when appropriate. (essential)
• Engages in collaborative meetings with other research groups. Attends and leads scientific seminars. (essential)
• Learns to identify, acknowledge and correct deficiencies in one’s own performance. (essential)
• Under the direction of PI, pursues/secures independent funding near the end of the fellowship. (essential)

Key Responsibilities:

• Conduct X-ray crystallography experiments to determine high-resolution structures of proteins involved in triglyceride metabolism.
• Apply cryo-EM techniques for structural analysis of protein complexes and interactions.
• Work collaboratively with the research team to design and execute experiments.
• Analyze and interpret experimental data, contributing to the preparation of scientific publications.
• Stay abreast of the latest developments in structural biology and lipid metabolism