FIXED TERM OF 3 YEARS | FULL TIME WITH 38,5 H | SALARY GRADE TV-L E13 | EUROPEAN INSTITUTE FOR MOLECULAR IMAGING

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in intravital microscopy in the Kiefer Lab at the European Institute for Molecular Imaging.
Uncontrolled inflammatory processes are at the basis of many widespread diseases including myocardial infarction, stroke and cancer. We aim to dissect mechanisms, which act on lymphatic vessels and immune cells and impact on development and resolution of inflammation. A key unknown during the course of inflammation remains the role of hypoxia. In this 3-year CRC (DFG)-funded position, we will use novel genetic reporters and transgenic models to specifically address the role of hypoxia during these processes using confocal and intravital microscopy.
The European Institute for Molecular Imaging (EIMI) is an interdisciplinary institute within the University of Münster developing imaging methods allowing to visualize molecular processes inside organisms, tissues and cells. With the help of imaging, we perform cutting-edge research in vascular, inflammatory, infectious, neurodegenerative diseases, and cancer. The EIMI is located in the Multiscale Imaging Center (MIC), which hosts research groups from our university combining a broad range of state-of-the-art imaging technologies for the investigation of biomedical questions.

REQUIREMENTS:

• The candidate must hold a PhD in life sciences (obtained no longer than 3 years ago)
• A strong interest and experience in confocal and / or intravital microscopy
• Experience in wet lab work with a solid foundation in basic molecular biology techniques
• Experience and qualification (license) in working with laboratory animals (mice)
• Curiosity and courage to contribute both to the development and application of new methods to investigate the dynamics and consequences of hypoxia in vivo in the context of different pathologies
• Excellent oral and written communication skills - English (required) and German (desired)
• Ability to work effectively in an interdisciplinary team
  We seek a highly motivated, ambitious, and talented young scientist to join an enthusiastic interdisciplinary team in an outstandingly equipped newly build scientific environment. Sound command of the basic wet lab technologies in biochemistry (DNA, RNA and protein) and previous experience in operating a high-end microscope (e.g., life cell, confocal microscopy or multiphoton) are required.

• Characterization of hypoxia reporter mice in vitro and in vivo
• Intravital imaging of genetically encoded hypoxia reporters in inflammatory disease models
• Development of improved genetically encoded hypoxia reporters