Principal Information Security Engineer at Mayo Career Site US

Rochester, Minnesota, United States -

Full Time

Start Date

Immediate

Expiry Date

16 Aug, 26

Salary

214760.0

Posted On

18 May, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Digital Forensics, Malware Reverse Engineering, Incident Response, Security Operations Center, AI-Enabled Security, Network Architecture, Vulnerability Analysis, Security Monitoring, Technical Leadership, Software Development, Risk Management, Security Analytics, Automation, Compliance, System Development Lifecycle, Technical Mentorship

Industry

Hospitals and Health Care

Description

The Principal Information Security Engineer in the Cybersecurity Operations Center provides leadership and senior level technical skills responsible for advancing the organization’s security operations, incident response capabilities, and overall security monitoring program maturity. Serves as an information security liaison, partnering closely with organizational units and stakeholders to provide deep subject matter expertise in security operations functions, incident response requirements, and responsible application of AI‑enabled security capabilities. Recognized as an expert in digital forensics and malware reverse engineering and plays a critical role during high‑impact cybersecurity incidents by advising and supporting incident handling activities, participation in an on‑call rotation for escalated and enterprise‑significant security events. Provides strong technical leadership to drive consistency and excellence across security operations through mentorship, training, and authoritative guidance. Drives program process improvements to ensure advanced analytics, automation, and artificial intelligence are leveraged to enhance detection, investigation, and response outcomes. Works closely with team members to provide technical decision‑making, complex problem solving, and cross‑team coordination to improve detection and response processes. Produce clear, actionable reporting, metrics, and investigative findings to support operational decision‑making, leadership visibility, and continuous improvement of security operations. Operates with a long‑term, systems‑level perspective, shaping how security capabilities are designed, implemented, and sustained, including the evaluation and integration of AI‑driven tools and techniques. Success in this role is measured by improved operational outcomes, reduced risk, increased response effectiveness, and the maturity and scalability of the organization’s security operations center and incident response practices. The Information Security Principal Engineer acts as an information security liaison to various business units and the Information Technology Department to provide direction, training, and guidance for OIS staff. The Information Security Principal Engineer is considered an expert, leader and mentor; identifying and resolving technology related information security gaps based on the organization’s risk posture. Specifically, the Information Security Principal Engineer is knowledgeable, proficient and experienced in: •Working with business partners across the organization to achieve organizational and OIS goals •Working collaboratively with team members and other leaders to develop and implement cybersecurity strategy based on industry best practice •Developing secure network and systems architecture •Analyzing technology security posture and appropriate use of security defenses •Matching technical solutions with business requirements and then designing and implementing them; •Software development, testing, support/problem solving, and overall technology administration; •Organizational procedures such as the system development lifecycle; •Use of defensive measures and information to identify, analyze and report security events; •Researching and understanding pertinent information technology laws, policies and procedures •Providing direct support for acquiring information security technology and applications •Applying IT-related laws and policies, and providing IT-related guidance throughout the software acquisition lifecycle •Collecting and analyzing information to identify vulnerabilities and potential for exploitation •Managing and administering processes and tools that enable the organization to identify, document, and access intellectual capital and information content •Executing duties governing hardware, software, and information system acquisition programs and other program management policies This is a hybrid position and incumbent must live within 100 miles of a Mayo Clinic campus. Mayo Clinic will not sponsor or transfer visas for this position including F1 OPT STEM. Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans [https://jobs.mayoclinic.org/benefits/] – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. Benefits Highlights * Medical: Multiple plan options. * Dental: Delta Dental or reimbursement account for flexible coverage. * Vision: Affordable plan with national network. * Pre-Tax Savings: HSA and FSAs for eligible expenses. * Retirement: Competitive retirement package to secure your future. Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. [https://jobs.mayoclinic.org/alllocations] Equal Opportunity All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" [https://www.eeoc.gov/poster]. Mayo Clinic participates in E-Verify [https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf] and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Responsibilities

Lead the Cybersecurity Operations Center by advancing security monitoring, incident response capabilities, and the integration of AI-driven security tools. Provide senior technical leadership and mentorship to improve detection, investigation, and overall organizational security posture.