Pay Range: $165,500.00-$272,900.00 Company Overview:
The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.
Job Description:
Exciting Opportunity at MSK: Principal, MSK Tx BridgeLabs Biologics, Drug Development
We are seeking a Principal, MSK Tx BridgeLabs Biologics, Drug Development to lead antibody discovery and protein engineering activities and designation of development candidates within MSK therapeutics bridge labs.
This role provides scientific and operational leadership across biologics projects, guiding antibody generation, screening, and optimization, and ensuring alignment with MSK’s broader drug development goals.

KEY QUALIFICATIONS:

• Doctorate’s Degree in Biology, Chemistry, Microbiology, Engineering, or equivalent (10 years).
• Extensive experience in biologics drug discovery and development.
• Successful leadership of antibody discovery and engineering teams.
• Track record of advancing biologics projects into clinical development.

CORE SKILLS

• Demonstrated scientific accomplishments in biologics development.
• Extensive experience with assay development and protein expression/purification.
• Strong communication and stakeholder engagement skills.
• Ability to thrive in a collaborative, entrepreneurial environment.
• Proven success in building and managing high-performing teams.

• Provide scientific expertise leadership on biologics drug discovery projects.
• Oversee antibody generation, screening, optimization, and engineering.
• Guide development and application of new assays for biologics.
• Ensure timely completion of biologics projects and refinement of leads.
• Generate robust data packages with the OEC Product Development Team to support commercial partnering.
• Coordinate internal resources and external CROs to ensure project success.
• Communicate progress with licensing managers, project managers, and OEC stakeholders.
• Support data generation on efficacy, PK/PD, toxicology, formulation, and scalability.
• Represent biologics projects in internal and external meetings and reviews.
• Participate in OEC initiatives, including the Entrepreneurship Initiative.
• Build and lead a high-performing biologics team, providing coaching and development.
• Maintain scientific rigor and up-to-date knowledge in biologics drug development.