Use Your Power for Purpose
At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. Your work will directly impact the development of therapies and vaccines that improve patients’ lives globally. By leveraging advanced science and cutting-edge technologies, you will play a crucial role in transforming innovative ideas into life-changing medical solutions. Whether you are involved in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your contributions will be vital in accelerating the delivery of top-tier medicines to patients worldwide.
What You Will Achieve
The Pfizer Oncology Research Unit is seeking a Principal Scientist to join our ADC Pharmacology team. The candidate will join an interdisciplinary and highly collaborative team to support and advance our preclinical ADC pipeline. The ideal candidate will have a strong background in cell and molecular biology, in vitro pharmacology, and automating the drug discovery process.

In this role, you will:

• Develop and Standardize ADC Screening Assays: Design, optimize, and validate in vitro screening assays to evaluate the mechanism of action of ADCs and ADC payloads.
• Implement and Optimize Automation Processes: Develop, implement, and continuously improve automated screening processes to enhance efficiency, accuracy, and throughput for ADC screening. This includes integrating robotics, software and data management systems to streamline workflows and reduce manual intervention.
• Collaborate with Cross-Functional Teams: Work closely with other scientists, researchers, and departments to ensure the successful progression of ADC projects.
• Manage CRO Partnerships: Oversee and coordinate with Contract Research Organizations (CROs) to develop and execute ADC screening programs. This includes defining project scopes, ensuring adherence to timelines and budgets, and quality control.
• Mentor and Train Junior Staff: Provide guidance and training to junior scientists and technicians in ADC screening techniques and best practices.
• Stay Current with Industry Trends: Keep up to date with the latest advancements in ADC technology and screening methodologies to ensure the company remains at the forefront of the field.
• Prepare and Present Reports: Compile comprehensive reports and present findings to stakeholders, including senior management and external partners.

Here Is What You Need (Minimum Requirements)

• BS with at least 12 years of experience or MS with at least 9 years of experience or PhD with at least 4 years of experience.
• Expertise in a variety of cell-based assays and technologies, including luminescence-based cell viability/cytotoxicity assays, HTRF, AlphLISA, HiBiT, and imaging.
• Experience in the development and standardization of in vitro cell-based screening assays to facilitate lead selection, including establishment of metrics and acceptance criteria for monitoring assay performance.
• Experience automating drug discovery workflows.
• Experience managing an independent research program with minimal supervision .
• Demonstrated ability tolead and inspire a diverse team, fostering a culture of accountability, collaboration, and continuous improvement to achieve goals.
• Strong problem-solving skills and the ability to apply novel and innovative approaches.
• Strong oral and written communication skills.
• Must be goal-oriented with the ability to handle multiple tasks and to prioritize.

Bonus Points If You Have (Preferred Requirements)

• PhD with 4+ years of relevant industry experience.
• Previous experience with ADCs and hands-on knowledge of the drug discovery process.
• Experience managing screening projects at CROs.
• Direct managerial experience in an industry research setting.

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform laboratory work and complex data analysis.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Working in a BSL-2 laboratory environment with appropriate personal protective equipment.

Additional Information:

• Work Location Assignment: On Premise
• Last Day to Apply: August 22, 2025

The annual base salary for this position ranges from $102,900.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development

• Develop and Standardize ADC Screening Assays: Design, optimize, and validate in vitro screening assays to evaluate the mechanism of action of ADCs and ADC payloads.
• Implement and Optimize Automation Processes: Develop, implement, and continuously improve automated screening processes to enhance efficiency, accuracy, and throughput for ADC screening. This includes integrating robotics, software and data management systems to streamline workflows and reduce manual intervention.
• Collaborate with Cross-Functional Teams: Work closely with other scientists, researchers, and departments to ensure the successful progression of ADC projects.
• Manage CRO Partnerships: Oversee and coordinate with Contract Research Organizations (CROs) to develop and execute ADC screening programs. This includes defining project scopes, ensuring adherence to timelines and budgets, and quality control.
• Mentor and Train Junior Staff: Provide guidance and training to junior scientists and technicians in ADC screening techniques and best practices.
• Stay Current with Industry Trends: Keep up to date with the latest advancements in ADC technology and screening methodologies to ensure the company remains at the forefront of the field.
• Prepare and Present Reports: Compile comprehensive reports and present findings to stakeholders, including senior management and external partners