Principal Scientist (Biochemistry/Enzymology)

at  Cancer Research UK

AT CANCER RESEARCH UK, WE EXIST TO BEAT CANCER.

We are professionals with purpose, beating cancer every day. But we need to go much further and much faster. That’s why we’re looking for someone talented, someone determined, someone like you.
We currently have an opportunity within our Drug Discovery team for an experienced and passionate Principal Scientist to bring scientific leadership to the design, prosecution and analysis of biochemical assays and bespoke mechanistic data, based at our Babraham Research Campus facilities in Cambridge. This is an exciting opportunity and time to join us as we further implement our 5-year plan.

ABOUT CRUK DRUG DISCOVERY

As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.
We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world class biology, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.

WHAT SKILLS WILL I NEED?

We are seeking an accomplished scientific expert with the following skills and experience:

• A BSc, MSc or PhD in biochemistry or in vitro pharmacology; relevant experience may be substituted for education
• Significant experience in a drug discovery environment of dissecting enzyme and small molecule inhibitor mechanisms
• Detailed understanding of steady-state and pre-steady-state enzymology. Experience in Modelling and Simulation will be an advantage.
• Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems
• Significant experience of assay development for a range of target classes
• Demonstrated scientific leadership skills with ability to give strategic direction
• Credible external reputation, as evidenced though publication, presentation at key conferences, and a strong personal network

Our organisation values are designed to guide all that we do .
Bold: Act with ambition, courage and determination
Credible: Act with rigour and professionalism
Human : Act to have a positive impact on people
Together: Act inclusively and collaboratively
We’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.
If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience we’d still love to hear from you.

Please refer the Job description for details