Principal Scientist, Cell-Free Protein Synthesis & Synthetic Biology

at  Generate Biomedicines

ABOUT GENERATE:BIOMEDICINES

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.
We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 300 employees.

Generate is seeking a highly creative and technologically curious Principal Scientist to be part of the CFPS (cell-free protein synthesis) group in our Innovation and Data Generation at Scale (IDGS) department. We believe innovations at the intersection of machine learning, computational protein design, and HTP experimentation will transform the way we bring new therapies to patients. They will contribute to efforts to expand our intrinsically scalable CFPS technology platform using synthetic biology, ML-guided optimization, and strain engineering to expand our intrinsically scalable CFPS technology platform, with the aim of increasing throughput, and dramatically shortening design-build-test cycles of novel biologics in the pre-IND pipeline. They will work to (1) further integrate CFPS technology into our HTP screening workflows at the intersection of synthetic biology, microfluidics, automation, and machine learning, 2) optimize and expand our CFPS workflows across modalities, and 3) work closely with our production scientists to design and implement productionized workflows.
The successful candidate has a proven track record of cross-disciplinary quantitative research, combining deep understanding of synthetic biology and high-throughput experimentation. Close collaboration with members from Generate’s Protein Sciences, Therapeutic Area Research, Computational, and Machine Learning teams will be crucial to produce game-changing novel CFPS workflows. This is an opportunity to perform highly innovative technology development, while being part of a collaborative and premier scientific environment in a well-funded biotech startup.