Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.
At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact.

QUALIFICATIONS & EXPERIENCE:

• PhD in Pharmacology, Pharmaceutical Sciences, Chemistry, or related field .
• 8+ years of relevant experience in bioanalytical sciences and pharmacokinetics within the pharmaceutical/biotech industry.
• Deep expertise in LC-MS/MS, Orbitrap, Q-TOF and HPLC methods.
• Strong background in PK modeling (WinNonlin, Phoenix, NONMEM, R, etc.) and interpretation of PK/PD data.
• Experience with regulatory submissions (FDA/EMA/ICH guidelines) and working in a GLP/GCP environment.
• Proven leadership skills with the ability to influence cross-functional teams and mentor junior scientists.
• Excellent communication, problem-solving, and project management abilities.
• Familiarity with DMPK principles (metabolism, transporters, drug-drug interactions).
• Knowledge of automation and high-throughput bioanalytical techniques.

PAY RANGE:

In the U.S., the hiring pay range for fully qualified candidates is $213,750-$236,250 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors.
Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.
Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.
Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.

• Lead the design, execution, and interpretation of bioanalytical (BA) and pharmacokinetic (PK) studies to support preclinical and clinical development.
• Hand-on and oversee method development, validation, and sample analysis for small molecules, and/or novel modalities (e.g., siRNA, PROTAC) using Sciex LC-MS/MS, Orbitrap, or Q-TOF machines
• Perform non-compartmental (NCA) and compartmental PK analysis, PK/PD modeling, and translational pharmacokinetics to guide compound optimization and dosing strategies.
• Author and review technical reports, regulatory submissions (INDs, NDAs, BLAs), and scientific publications.
• Collaborate closely with toxicology, clinical pharmacology, CMC, and discovery teams to ensure suitable study design and robust PK/PD understanding of drug candidates.
• Leveraging specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making
• Manage external CROs for bioanalytical and PK studies, ensuring data quality and regulatory compliance (GLP/GCP).
• Mentor junior scientists and contribute to departmental initiatives to enhance scientific and operational excellence.
• Capable of independently troubleshooting and resolving Sciex LC-MS/MS challenges as they arise in the lab.