Principal Scientist - Translational Intestinal Immunology (80-100%*) at Novartis

Basel, Basel-City, Switzerland -

Full Time

Start Date

Immediate

Expiry Date

05 Jul, 26

Salary

0.0

Posted On

06 Apr, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Mucosal Immunology, Gastroenterology, Translational Research, Flow Cytometry, Cell Biology, Molecular Biology, Target Discovery, Biomarker Development, Drug Discovery, Transcriptomics, In Vitro Models, Data Analysis, Experimental Design, Preclinical Research, Clinical Research

Industry

Pharmaceutical Manufacturing

Description

Band Level 4 Job Description Summary Location: Basel, Switzerland Full time, onsite, #LI-Onsite In the Immunology group in Biomedical Research, We are developing the next generation of medicines for inflammatory bowel disease with the ambition to transform the lives of patients. This is an opportunity for you to bring your scientific talent and curiosity into a highly collaborative, interdisciplinary environment, where your work will turn complex human data into actionable therapy-relevant insights in a competitive and dynamic field. Job Description The Translational Inflammatory Bowel Disease (IBD) lab is integrated in the Immunology Research Disease Area and will accelerate target discovery and positioning of therapeutic compounds for IBD (Ulcerative Colitis, Crohn’s disease). To lead the lab research activities, we are looking for a scientist who has a strong background in mechanistic translational research in mucosal immunology. If you are passionate about the molecular basis of IBD and compound mode of action at the interface of preclinical and clinical research, we want you on our team. Key Responsibilities Design and execute mechanistic experiments hands-on, to link human disease biology to druggable targets within and beyond the immune system, and to accelerate preclinical compound development, strengthen understanding of drug modes of action, differentiate novel drugs to standard-of care treatment. Leverage human biosamples (e.g. blood, intestinal biopsies) to generate decision-making data and position candidate molecules for clinical trials (target validation, MoA studies, biomarker strategy). Partner closely with early clinical teams (Biomarker Development, Translational Medicine) to test clinical hypotheses for early clinical strategies (e.g. patient stratification). Champion data-driven target discovery, in collaboration with data scientists, in vivo biology labs and other groups in Novartis Biomedical Research to connect quantitative methods (e.g. ex vivo analyses, transcriptomics) to patient heterogeneity and outcomes. Drive a culture of collaboration, talent development and integrity. Minimum Requirements Ideally PhD or MD qualified in Mucosal Immunology, Gastroenterology, Barrier Immunology (skin/lung/intestine), or a related field with a strong track record of peer-reviewed publications. At least 3 years of relevant translational research expertise in an interdisciplinary setting in academia or industry, bridging clinical and preclinical evidence Hands-on mastery of routine immunological/ cell biology/ molecular biology assays (e.g. multi-parametric flow cytometry) and in vitro human models relevant to IBD and mucosal immunity (e.g. primary immune/epithelial cells, slice cultures). Proven ability to conduct experiments using in vitro human systems and biosamples (e.g., PBMCs, primary immune/epithelial cells, tissue explants), including sample-tracking best practices and consent/ethics). Experienced in collaboration with data scientists, ensuring high quality experimental design and reproducibility. Proven track record of completing projects on schedule in view of narrow timelines Additional Requirements Prior experience mentoring junior researchers would be an advantage Experience contributing to drug discovery programs in biotech/pharma or translational academic/clinical setting (e.g. in vitro pharmacology, biomarker studies) is a plus. Data Science literacy and confidence in interpreting multi‑omic outputs and statistical analyses is an additional asset. *Restrictions on flexible working requirements may apply and can be discussed at interview stages as necessary Accessibility and accommodation: Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Skills Desired Gastroenterology, Gastrointestinal Disease, Inflammatory Bowel Diseases Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing people’s lives. Novartis is aware of employment scams which make false use of our company name or leader’s names or recruiter’s names to defraud job seekers. Novartis does not make job offers without interview and never asks candidates for money. If you have encountered a job posting or been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond, send money or personal information. In the context of China Cross-Border Data Transfer (CBDT) policy, if you need to apply for a position in China, please go to the local Recruiting System TaleNov .

Responsibilities

Design and execute mechanistic experiments to link human disease biology to druggable targets and accelerate preclinical compound development. Collaborate with clinical teams to leverage human biosamples for target validation, biomarker strategy, and clinical trial positioning.