THE OPPORTUNITY

At Genentech and Roche, we’re at the forefront of a revolutionary transformation in drug discovery powered by AI and machine learning. Our “lab in the loop” strategy processes massive quantities of experimental data to train AI models that accelerate the discovery of new medicines.
To enable this vision, we’re seeking an exceptional Principal/Senior Principal Software Engineer to lead the development of our next-generation Therapeutic Molecule Registration (TMR) platform - a foundational component of our AI-driven drug discovery infrastructure.
This platform will serve as the central nervous system for managing and integrating molecular data across our global research organization, handling hundreds of billions of records and enabling unprecedented scale in virtual molecule design and testing. As the volume of AI-generated molecular designs grows exponentially, our TMR platform must evolve to become a high-performance, cloud-native system capable of supporting rapid iteration cycles between computational design and experimental validation. You will be instrumental in consolidating our molecule registration systems into a single, harmonized environment, unlocking the full potential of our data and accelerating the development of life-changing therapies.

• You are someone who combines deep technical expertise in building reliable, scalable software systems with proven technical leadership experience.
• You will excel at creating technical roadmaps, designing service architectures, and leading a small team of software engineers to execute on this transformative vision.
• You will work closely with Genentech Computational Sciences (gCS) colleagues, including our machine learning for drug development team, Genentech Research & Early Development (gRED) Drug Discovery teams including the Antibody Engineering division, and other teams across the Roche family of companies to identify, strategize, and productionalize high-impact applications from across the drug discovery and development pipeline.
• You will provide technical leadership in the design, development, and implementation of a cutting-edge therapeutic molecule registration platform.
• You will design and implement scalable, robust, and maintainable solutions that can handle massive data volumes (100M+ molecules) and support evolving business needs.
• You will directly contribute to accelerating drug discovery by improving data accessibility, enabling faster decision-making, and unlocking the full potential of our molecule data.
• You will utilize modern cloud-native technologies (AWS), advanced data systems, and innovative approaches to data management.