The Chan Zuckerberg Initiative was founded by Priscilla Chan and Mark Zuckerberg in 2015 to help solve some of society’s toughest challenges — from eradicating disease and improving education to addressing the needs of our local communities. Our mission is to build a more inclusive, just, and healthy future for everyone.

THE OPPORTUNITY

We are seeking an experienced Principal Technical Program Manager to report to the Vice President of Imaging Science and support cross-functional teams in the planning, execution, and delivery of ambitious imaging science and technology projects. The ideal candidate will combine strong technical knowledge with exceptional program management skills to guide complex initiatives from conception to scalable implementation.
This role will play a key part in developing innovative technologies and ensuring they are positioned for broad impact — including successful translation and adoption across academic research institutions and commercial industry settings. The Technical Program Manager will shape the execution required to scale scientific tools and platforms in a way that supports CZI Imaging Institute’s mission to democratize access and maximize global scientific benefit.
This on-site position will be based in San Francisco, CA.

BENEFITS FOR THE WHOLE YOU

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.

• CZI provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.
• CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.
• Paid time off to volunteer at an organization of your choice.
• Funding for select family-forming benefits.
• Relocation support for employees who need assistance moving to the Bay Area
• And more!

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
Explore our work modes, benefits, and interview process at www.chanzuckerberg.com/careers.
#LI-Onsite

• Coordinate multidisciplinary teams in the planning, execution, and scaling of complex imaging technology projects that bridge scientific discovery and translational application, with direct alignment to biological use cases.
• Lead cross-functional project planning with a focus on transitioning prototype technologies into scalable, reproducible tools that can be adopted across diverse academic and commercial environments.
• Develop comprehensive project roadmaps including scope, scale-up strategy, timelines, resource allocation, risk assessments, commercialization pathways, and budgets.
• Manage cross-platform integration and execution across hardware, software, probes, and data science teams, ensuring readiness for broader deployment.
• Track impact metrics including publications, platform performance, and adoption metrics across both research and industry ecosystems.
• Proactively identify scalability bottlenecks and dependencies, and implement mitigation plans to enable sustainable, widespread technology use.
• Serve as a liaison between scientific researchers, productization teams, and industry collaborators to ensure successful technology transfer and scaling pathways.
• Communicate project milestones and risks clearly to stakeholders across technical and non-technical domains.