JOB SUMMARY:

The Senior Development Scientist is responsible for designing, developing, and optimizing synthetic processes for peptides and/or oligonucleotides to support both clinical and commercial manufacturing. This role plays a key part in the technical execution of development projects, leading experimental design, process scale-up, and transfer activities while working closely with cross-functional teams to ensure regulatory and quality standards are met. This role contributes directly to PolyPeptide’s commitment to delivering exceptional quality and on-time delivery to our customers.

EDUCATION & EXPERIENCE

Required Education:

• Ph.D. in Organic Chemistry, Biochemistry, Chemical Engineering, or a related field; or Master’s degree in the same fields with equivalent industry experience.

Experience

• Minimum 3 years of relevant industry experience with a Ph.D.
• Minimum 6 years of relevant industry experience with a Master’s degree
• Experience in peptide or oligonucleotide synthesis, process development, scale-up, and technology transfer

• Familiarity with GMP manufacturing and regulatory requirements for clinical and commercial API production

SKILLS & COMPETENCIES

Technical Skills:

• Proven experience in peptide or oligonucleotide synthesis, process development, and scale-up.
• Strong knowledge of solid-phase and/or solution-phase synthesis techniques.
• Familiarity with GMP manufacturing and regulatory expectations for clinical and commercial API production.
• Hands-on experience with analytical tools such as HPLC, LC-MS, NMR, and UV-Vis

Soft Skills:

• Excellent problem-solving, documentation, and communication skills.
• Ability to manage multiple priorities in a fast-paced, collaborative environment.

Competencies:

• Analytical Thinking & Problem Solving
• Technical Leadership & Mentorship
• Collaboration & Cross-Functional Communication
• Initiative & Innovation
• Attention to Detail & Documentation Rigor

• Lead the design and development of robust, scalable synthetic routes for peptides and/or oligonucleotides.
• Plan and execute laboratory studies for process optimization, scale-up, and technology transfer to GMP manufacturing.
• Develop and evaluate purification and isolation strategies including HPLC, preparative chromatography, and lyophilization techniques.
• Interpret analytical data and collaborate with Quality Control and Analytical Development teams to support characterization and release testing.
• Draft and review technical reports, batch records, development protocols, and regulatory documentation.
• Mentor junior scientists and provide technical leadership within the Development group.
• Identify and troubleshoot issues in synthesis, purification, or scale-up processes.
• Contribute to continuous improvement initiatives and innovation in synthetic methodologies.
• Participate in cross-functional meetings with Project Management, Manufacturing, QA, and Regulatory teams to align on project goals and timelines.
• Support customer audits and regulatory inspections as a subject matter expert.