JOB DESCRIPTION

Twist Bioscience is expanding our protein capabilities to support a growing portfolio of products. We’re looking for a Protein Scientist with strong technical skills, hands-on experience in protein characterization techniques, as well as a passion for developing and implementing new technologies in a manufacturing environment.
As a member of the Tech Transfer team, you will develop, troubleshoot, and refine methods to establish robust workflows that can be seamlessly executed by the manufacturing team for high-throughput processing. You will collaborate with our subject matter experts located in Twist’s San Francisco and Boston labs as well as with manufacturers to bring new capabilities into production. You will also be required to troubleshoot challenges that arise in manufacturing settings as the subject matter expert at Twist Wilsonville. This role provides the opportunity to work cross-functionally with R&D scientists, automation & software engineers, bioinformaticists, and manufacturers in a fast-paced, innovation-driven company.
If you thrive in a multidisciplinary team environment where every day is different, accelerate at executing a variety of processes at the lab bench, and are a creative problem solver with a passion for delivering high-quality results with careful experimental execution, we want you to apply!

QUALIFICATIONS AND REQUIRED SKILLS

• Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or a related field, or M.S. with 2–5 years of relevant industry experience.
• Strong hands-on experience in protein purification and characterization techniques.
• Familiarity with analytical methods such as SEC, DLS, DSF, BLI, SPR, MS, enzymatic activity assays, among others.
• Background in protein chemistry is strongly preferred.
• Excellent problem-solving skills, scientific judgment, and attention to detail.
• Strong interpersonal and communication skills with the ability to work in a collaborative, cross-disciplinary environment.
• Ability to troubleshoot, train, and mentor others in experimental workflows and data interpretation

PREFERRED SKILLS

• Ability to multitask and thrive in a fast-paced and challenging environment.
• Work cross-functionally within and across the department effectively as a team player.
• Excellent problem-solving capabilities.
• Programming experience (ideally SQL, JSON, or Python) for manipulating and analyzing large datasets.
• Familiarity with various sequencing platforms such as Illumina NGS.
• Experience with various high-throughput automation platforms.
• Understanding of ISO 13485 and regulated environments for molecular diagnostics or NGS kits.

• Design and implement workflows for biophysical and functional characterization of IgG and recombinant proteins, including SEC, DLS, DSF, BLI, SPR, MS, and additional downstream assays as needed.
• Support the transfer of protein-based workflows to production, including method optimization, documentation, and training of manufacturing staff.
• Lead efforts to insource protein production, including evaluation of expression systems, purification workflows, and performance benchmarking.
• Author technical documents, protocols, training guides, and validation reports to ensure smooth process implementation and knowledge transfer.
• Analyze complex experimental datasets and contribute to data-driven troubleshooting and continuous process improvement.
• Collaborate in cross-functional project teams representing protein science in core team meetings and contributing to strategic decisions.
• Document work in electronic lab notebooks and communicate results to stakeholders clearly and regularly.