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ABOUT THE ROLE

The Ye lab invite applications from talented, highly motivated, and ambitious scientists for a Research Assistant position leading one or more projects examining changes in synapse biology associated with Parkinson’s disease and characterise proteostasis mechanisms to intervene in disease development.

WHAT YOU WOULD BE DOING

The project will unveil changes to proteomics and proteasome activities associated with the disease, and define how synaptoneurosomes are affected by pathological aggregate structures. This knowledge will allow better understanding of how pathological aggregates may alter the proteostasis mechanisms specific to the synapse and thereby re-define local protein landscape. You will use a multidisciplinary approach (protein biochemistry, advanced microscopy and various cell biology techniques) to identify the types of modifications and potential factors that are associated with the pathological synapse structures.

This role is part of the Department of Brain Sciences at Imperial College London, located in Sir Michael Uren Hub. As a Research Assistant in the Ye lab, you will:

• Build on your existing skills and experience to address major components of this project independently.
• Present research findings as written reports, at conferences, within the College and as published manuscripts.
• Take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers.
• Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students.
• Provide guidance to staff and assist in the supervision of undergraduate and postgraduate research students, as required.
• Maintain highly organised and accurate records of experimental work.
• Undertake appropriate scientific and professional training